1例合并桥本甲状腺炎的恶性淋巴瘤病例报告

A case report of malignant lymphoma with Hashimoto's thyroiditis.

作者信息

Noguchi M, Mori N, Kojima M, Ono T

出版信息

Am J Clin Pathol. 1985 May;83(5):650-5. doi: 10.1093/ajcp/83.5.650.

DOI:10.1093/ajcp/83.5.650

Abstract

The authors studied a case of malignant lymphoma arising in a patient with Hashimoto's thyroiditis. Histologically, a malignant, large cell, immunoblastic lymphoma was revealed, with the surrounding area showing changes typical of Hashimoto's thyroiditis. Immunoperoxidase staining proved the lymphoma cells to have intracytoplasmic immunoglobulins (IgA, k). Infiltrating interfollicular plasma cells containing the same kind of intracytoplasmic immunoglobulins (IgA, k) were present in the surrounding Hashimoto's thyroiditis lesions. Thus, it is possible that the interfollicular infiltrating plasma cells evolved into a malignant lymphoma in this case of Hashimoto's thyroiditis.

摘要

作者研究了一例发生于桥本甲状腺炎患者的恶性淋巴瘤病例。组织学检查显示为恶性大细胞免疫母细胞淋巴瘤，其周围区域呈现出桥本甲状腺炎的典型变化。免疫过氧化物酶染色证实淋巴瘤细胞含有胞浆内免疫球蛋白（IgA，κ）。在周围的桥本甲状腺炎病变中存在含有相同类型胞浆内免疫球蛋白（IgA，κ）的滤泡间浸润浆细胞。因此，在该例桥本甲状腺炎中，滤泡间浸润浆细胞有可能演变成了恶性淋巴瘤。