Averback P, Salama S S, Moinuddin M
Can Med Assoc J. 1977 Jul 9;117(1):41-3.
Light and electron microscopic study of the thyroid gland and an enlarged cervical lymph node in a 75-year-old woman with Hashimoto's thyroiditis disclosed immunoblastic proliferation in the lymph node, marked by collections of striking round cells positive to periodic acid-Schiff (PAS) staining, immunoblasts and plasmacytoid elements in a vascular, fibrous framework. The PAS-positive cells ("macaroni cells") were distended with whorls of angulated tubular material resembling endoplasmic reticulum. Parafollicular-cell hyperplasia and an atypical plasmacytoid focus were noted in the thyroid. Hashimoto's disease is known to be associated with malignant lymphoma, as are autoimmune and malignant diseases with immunoblastic lymphadenopathy. This is the first report of the association of Hashimoto's disease and immunoblastic lymphadenopathy. The atypical plasma cells have not previously been described.
对一名患有桥本甲状腺炎的75岁女性的甲状腺及肿大的颈部淋巴结进行光镜和电镜研究发现，淋巴结中有免疫母细胞增殖，其特征为大量对过碘酸希夫（PAS）染色呈阳性的显著圆形细胞、免疫母细胞以及血管性纤维框架中的浆细胞样成分聚集。PAS阳性细胞（“通心粉细胞”）充满了呈角状的管状物质的漩涡，类似于内质网。甲状腺中可见滤泡旁细胞增生和一个非典型浆细胞样病灶。众所周知，桥本氏病与恶性淋巴瘤有关，自身免疫性疾病和恶性疾病与免疫母细胞性淋巴结病也有关。这是关于桥本氏病与免疫母细胞性淋巴结病关联的首次报告。此前尚未描述过这种非典型浆细胞。
