Duby A D, Klein K A, Murre C, Seidman J G
Science. 1985 Jun 7;228(4704):1204-6. doi: 10.1126/science.3839095.
The T-cell antigen receptor is a cell surface molecule vital in mediating the cellular immune response. The arrangement and rearrangement of the gene segments encoding the beta-chain polypeptide of the receptor are similar to those of immunoglobulin gene segments. The two constant region genes of the human T-cell antigen receptor are 8 kilobases apart with a cluster of joining segments located 5' of each constant region gene. Although most beta-chain gene rearrangements involve the variable, diversity, and joining segments, analysis of a beta-chain complementary DNA clone suggests the occasional occurrence of another type of rearrangement.
T细胞抗原受体是一种在介导细胞免疫反应中至关重要的细胞表面分子。编码该受体β链多肽的基因片段的排列和重排与免疫球蛋白基因片段的排列和重排相似。人类T细胞抗原受体的两个恒定区基因相隔8千碱基，每个恒定区基因的5'端都有一组连接片段。尽管大多数β链基因重排涉及可变区、多样性区和连接区片段，但对一个β链互补DNA克隆的分析表明偶尔会发生另一种类型的重排。
