Abbas Rim, Chakkour Mohamed, Zein El Dine Hiba, Obaseki Eseiwi Folorunsho, Obeid Soumaya T, Jezzini Aya, Ghssein Ghassan, Ezzeddine Zeinab
Faculty of Health Sciences, Beirut Arab University, Beirut P.O. Box 11-5020, Lebanon.
Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.
Biology (Basel). 2024 Jan 27;13(2):78. doi: 10.3390/biology13020078.
The opportunistic pathogen () can colonize mucosal surfaces and spread from mucosae to other tissues, causing fatal infections. Medical equipment and the healthcare setting can become colonized by species, which are widely distributed in nature and can be found in water, soil, and animals. Moreover, a substantial number of community-acquired illnesses are also caused by this organism worldwide. These infections are characterized by a high rate of morbidity and mortality as well as the capacity to spread metastatically. Hypervirulent strains are thought to be connected to these infections. Four components are critical to this bacterium's pathogenicity-the capsule, lipopolysaccharide, fimbriae, and siderophores. Siderophores are secondary metabolites that allow iron to sequester from the surrounding medium and transport it to the intracellular compartment of the bacteria. A number of variables may lead to colonization in a specific area. Risk factors for infection include local healthcare practices, antibiotic use and misuse, infection control procedures, nutrition, gender, and age.
机会性病原体（）可定植于黏膜表面，并从黏膜扩散至其他组织，引发致命感染。医疗设备及医疗环境可被 菌属定植，该菌属在自然界广泛分布，可在水、土壤及动物中发现。此外，在全球范围内，大量社区获得性疾病也是由这种微生物引起的。这些感染的特点是发病率和死亡率高，且具有转移性扩散的能力。高毒力 菌株被认为与这些感染有关。四种成分对该细菌的致病性至关重要——荚膜、脂多糖、菌毛和铁载体。铁载体是次生代谢产物，可使铁从周围介质中螯合出来，并将其转运至细菌的细胞内区室。许多因素可能导致 在特定区域定植。感染的危险因素包括当地的医疗行为、抗生素的使用和滥用、感染控制程序、营养状况、性别和年龄。
