5-表异帕米星（Sch 22591）在人体志愿者中的单剂量药代动力学。
The single-dose pharmacokinetics of 5-epi-sisomicin (Sch 22591) in human volunteers.
作者信息
Amirak I D, Williams R J, Chung M, Noone P
出版信息
J Antimicrob Chemother. 1985 May;15(5):607-11. doi: 10.1093/jac/15.5.607.
PMID:3839236
Abstract
5-epi-sisomicin was given as a single 1 mg/kg intramuscular injection to six adult male volunteers. No adverse effects were observed and the pharmacology was very similar to that of sisomicin. The extended spectrum of 5-epi-sisomicin and its enhanced antipseudomonal activity prompt further clinical evaluation of this agent.
摘要
对6名成年男性志愿者单次肌肉注射1毫克/千克的5-表紫苏霉素。未观察到不良反应，其药理作用与紫苏霉素非常相似。5-表紫苏霉素的广谱抗菌活性及其增强的抗假单胞菌活性促使对该药物进行进一步的临床评估。
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