西索米星的药代动力学参数。
Pharmacokinetic parameters of sisomicin.
作者信息
Meyers B R, Hirschman S Z, Yancovitz S, Ribner B
出版信息
Antimicrob Agents Chemother. 1976 Jul;10(1):25-7. doi: 10.1128/AAC.10.1.25.
Abstract
Sisomicin in doses of 1 mg/kg was administered intramuscularly to 10 healthy volunteers, and 1 week later the same volunteers received sisomicin at the same dose intravenously. A peak serum concentration of sisomicin of 3.08 mug/ml was obtained 1 h after intramuscular injection, and a peak serum concentration of 7.12 mug/ml was achieved 30 min after a 30-min intravenous infusion. The sisomicin elimination data were analyzed according to a two-compartment model. Pharmacokinetic parameters derived from the intramuscular and intravenous studies were quite similar.
摘要
以1mg/kg的剂量给10名健康志愿者肌内注射西索米星，1周后，同样的志愿者接受相同剂量的西索米星静脉注射。肌内注射后1小时，西索米星的血清峰值浓度为3.08μg/ml，在30分钟静脉输注后30分钟，血清峰值浓度达到7.12μg/ml。根据二室模型分析西索米星的消除数据。肌内注射和静脉注射研究得出的药代动力学参数非常相似。
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