恶性淋巴瘤中的两条14号染色体长臂增加：14号染色体长臂上关键的细胞遗传学改变

Two 14q+ chromosomes in malignant lymphoma: crucial cytogenetic changes on 14q.

作者信息

Ohyashiki K, Yoshida M A, Ohyashiki J, Koch F, Han T, Sandberg A A

出版信息

Cancer Genet Cytogenet. 1985 Aug;17(4):325-31. doi: 10.1016/0165-4608(85)90116-5.

Abstract

We encountered a 36-year-old white male patient with poorly differentiated lymphocytic lymphoma, whose lymph node cells showed a clonal cytogenetic change involving chromosome #14, i.e., 47,XY, + 2,der(14),t(14;14)(14pter----14q32;14q24----14q32++ +). In addition to this change, cells with a translocation between chromosomes #2 and another #14 [t(2;14)(q21;q24)], as well as a missing chromosome #8 were found. We have reviewed the literature dealing with two or more changes affecting chromosome #14 and discussed the importance of the cytogenetic change at band 14q32 in malignant lymphoma.

摘要

我们遇到一名36岁的白人男性患者，患有低分化淋巴细胞淋巴瘤，其淋巴结细胞显示出涉及14号染色体的克隆性细胞遗传学改变，即47,XY, + 2,der(14),t(14;14)(14pter----14q32;14q24----14q32++ +)。除了这种改变外，还发现了2号染色体与另一条14号染色体之间发生易位的细胞[t(2;14)(q21;q24)]，以及一条缺失的8号染色体。我们查阅了涉及影响14号染色体的两种或更多种改变的文献，并讨论了14q32带的细胞遗传学改变在恶性淋巴瘤中的重要性。