Oshimura M, Ohyashiki K, Tonomura A, Terada H
Cancer Genet Cytogenet. 1981 Nov;4(3):245-50. doi: 10.1016/0165-4608(81)90018-2.
A 17-year-old Japanese boy with Down's syndrome developed leukemic lymphosarcoma; histology of a lymph node biopsy revealed a malignant lymphoma, of the poorly differentiated lymphocytic (ML-PDL) or possibly lymphoblastic type (ML-LB). The Giemsa-banding technique for chromosome analysis revealed the karyotype of the lymphoma cells to be 47, XY, + 21, 14q+. A chromosome study of PHA-stimulated lymphocytes showed a 21-trisomic pattern, i.e., 47, XY, + 21. The 14q+ marker was a product of a translocation in which the long arm of chromosome No. 8 (probable break at band q11) was translocated to the long arm of a No. 14 at band q32, which is a region usually affected in various types of lymphomas. Two normal No.8 chromosomes were present. Thus, the lymphoma cells were partially trisomic for chromosome No. 8.
一名17岁患唐氏综合征的日本男孩患上了白血病性淋巴肉瘤；淋巴结活检的组织学检查显示为恶性淋巴瘤，属于低分化淋巴细胞型（ML-PDL）或可能是淋巴母细胞型（ML-LB）。采用吉姆萨显带技术进行染色体分析，结果显示淋巴瘤细胞的核型为47, XY, + 21, 14q+。对PHA刺激的淋巴细胞进行染色体研究显示为21-三体模式，即47, XY, + 21。14q+标记是一次易位的产物，其中8号染色体长臂（可能在q11带处断裂）易位至14号染色体长臂的q32带，该区域通常在各类淋巴瘤中会受到影响。存在两条正常的8号染色体。因此，淋巴瘤细胞对于8号染色体呈部分三体状态。
