2014 - 2016年酒精与大麻同时使用和大麻相关问题之间的关联：来自华盛顿小组调查的证据
Associations between simultaneous use of alcohol and cannabis and cannabis-related problems in 2014-2016: evidence from the Washington panel survey.
作者信息
Zhu Yachen, Ye Yu, Greenfield Thomas K, Kerr William C
机构信息
Alcohol Research Group, Public Health Institute, Emeryville, CA, 94608, USA.
出版信息
J Cannabis Res. 2024 Feb 24;6(1):8. doi: 10.1186/s42238-024-00217-z.
BACKGROUND
To address the research question of how simultaneous users of alcohol and cannabis differ from concurrent users in risk of cannabis use problems after the recreational marijuana legalization in Washington State.
METHODS
We used generalized estimating equations with a Poisson distribution to analyze the association between simultaneous use of alcohol and marijuana (SAM) and cannabis-related problems compared to concurrent use. The data is a longitudinal sample of drinkers and cannabis users (n = 257, 47% female) aged 18 years and older from Washington State in 2014-2016. We adjusted for survey weights to account for differential probability of selection and response rates. The primary outcome is the past-six-month CUDIT problem subscale (ranging from 0 to 28), which is the total score for seven CUDIT problem items, after excluding the three items that covered marijuana use frequency. Covariates include marijuana use frequency (daily/near daily use, regular use, or infrequent use), marijuana daily quantity, alcohol daily volume, panel survey cycle, medical marijuana recommendation, driving time to nearest marijuana outlet, age of marijuana use onset, and other demographics.
RESULTS
After adjusting for covariates, we found that compared to concurrent use, SAM was significantly positively associated with CUDIT problem subscale (IRR = 1.68, 95% CI: 1.25-2.27, p < 0.001); daily/near daily use of marijuana was strongly significantly associated with CUDIT problem subscale compared with infrequent use (IRR = 5.1, 2.71-9.57, p < 0.001) or regular use (IRR = 3.05, 1.91-4.85, p < 0.001). Secondary analyses using CUDIT total score as the outcome also showed a significant positive association with SAM compared to concurrent use (IRR = 1.17, 1.02-1.34, p < 0.05).
CONCLUSIONS
This study highlighted the importance of SAM, in addition to cannabis use frequency for predicting cannabis-related problems.
背景
为解决在华盛顿州休闲大麻合法化后，同时使用酒精和大麻的人群与并发使用者在大麻使用问题风险方面有何不同这一研究问题。
方法
我们使用具有泊松分布的广义估计方程来分析与并发使用相比，同时使用酒精和大麻（SAM）与大麻相关问题之间的关联。数据是2014 - 2016年来自华盛顿州18岁及以上饮酒者和大麻使用者的纵向样本（n = 257，47%为女性）。我们对调查权重进行了调整，以考虑不同的选择概率和回复率。主要结果是过去六个月的CUDIT问题子量表（范围从0到28），这是七个CUDIT问题项目的总分，不包括涵盖大麻使用频率的三个项目。协变量包括大麻使用频率（每日/接近每日使用、经常使用或不经常使用）、大麻每日用量、酒精每日摄入量、面板调查周期、医用大麻推荐、开车到最近大麻销售点的时间、大麻使用开始年龄以及其他人口统计学特征。
结果
在对协变量进行调整后，我们发现与并发使用相比，SAM与CUDIT问题子量表显著正相关（发病率比[IRR] = 1.68，95%置信区间：1.25 - 2.27，p < 0.001）；与不经常使用（IRR = 5.1，2.71 - 9.57，p < 0.001）或经常使用（IRR = 3.05，1.91 - 4.85，p < 0.001）相比，每日/接近每日使用大麻与CUDIT问题子量表显著正相关。以CUDIT总分作为结果的二次分析也显示，与并发使用相比，SAM与之显著正相关（IRR = 1.17，1.02 - 1.34，p < 0.05）。
结论
本研究强调了除大麻使用频率外，SAM对于预测大麻相关问题的重要性。
Zotero 插件