肾脏疾病中的蛋白C活性

Protein C activity in renal disease.

作者信息

Sørensen P J, Knudsen F, Nielsen A H, Dyerberg J

出版信息

Thromb Res. 1985 May 1;38(3):243-9. doi: 10.1016/0049-3848(85)90152-5.

Abstract

Protein C activity was determined in 19 healthy controls and in 52 patients with renal diseases, clinically divided into three groups I) Nephrotic syndrome, II) Renal insufficiency, III) Terminal uremia, requiring maintenance dialysis. In the nephrotic syndrome protein C levels were found to be normal, but in renal insufficiency and terminal uremia the protein C activity was significantly decreased. A correlation between decreasing protein C and progressive renal failure is suggested. The reduced protein C activity may play an important role in the thrombotic tendency seen in renal diseases and uremia.

摘要

对19名健康对照者以及52名患有肾脏疾病的患者测定了蛋白C活性，这些患者临床上分为三组：I）肾病综合征，II）肾功能不全，III）终末期尿毒症，需要维持性透析。发现在肾病综合征中蛋白C水平正常，但在肾功能不全和终末期尿毒症中蛋白C活性显著降低。提示蛋白C降低与进行性肾衰竭之间存在相关性。蛋白C活性降低可能在肾脏疾病和尿毒症中出现的血栓形成倾向中起重要作用。