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光生物调节缓解灼口综合征疼痛:即时和每周结果探讨。

Photobiomodulation alleviates Burning Mouth Syndrome pain: Immediate and weekly outcomes explored.

机构信息

Department of Oral Medicine, Sedation and Imaging, Hadassah Medical Center, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel.

出版信息

Oral Dis. 2024 Oct;30(7):4668-4676. doi: 10.1111/odi.14900. Epub 2024 Feb 23.

Abstract

UNLABELLED

Burning Mouth Syndrome (BMS) is an intraoral chronic burning or dysesthetic sensation, without clinically evident causative lesions on clinical examination and investigation.

AIM

To assess immediate and weekly effects of photobiomodulation (PBM) on BMS patients.

METHODS

Thirty BMS patients were treated intra-orally with photobiomodulation 940(±10) nm (InGaAsP) 3 W, semi-conductor diode, weekly, for up to 10 weeks. Pain intensity, measured using the Visual Analogue Scale (VAS), and characteristics were recorded immidiately after each treatment, along with a weekly average VAS.

RESULTS

Immediate mean VAS score decreased from a starting score of 7.80 ± 1.83 to 2.07 ± 2.55 (p < 0.001). The mean weekly VAS score for the week after the final treatment session was higher (5.73 ± 2.80, p < 0.001) than the immediate response, but still significantly lower than the starting score (p = 0.017). We observed a trend of pain improvement with more treatments, but this was only statistically significant up to the third treatment. Male gender and unilateral pain correlated with better PBM efficacy (p = 0.017, 0.022, respectively).

CONCLUSION

PBM provides significant immediate pain relief for BMS patients after each treatment; however, the efficacy decreases notably over the following week. A trend of increasing pain relief across treatments was observed, statistically significant up to the third treatment.

摘要

目的

评估光生物调节(PBM)对灼口综合征(BMS)患者的即刻和每周疗效。

方法

30 例 BMS 患者每周接受一次口腔内 940(±10)nm(InGaAsP)3W、半导体二极管的 PBM 治疗,最多持续 10 周。在每次治疗后立即以及每周平均视觉模拟量表(VAS)记录疼痛强度和特征。

结果

即刻平均 VAS 评分从 7.80±1.83 降至 2.07±2.55(p<0.001)。最后一次治疗后一周的每周平均 VAS 评分较高(5.73±2.80,p<0.001),但仍明显低于起始评分(p=0.017)。我们观察到随着治疗次数的增加疼痛改善的趋势,但仅在第三次治疗时具有统计学意义。男性性别和单侧疼痛与更好的 PBM 疗效相关(p=0.017、0.022)。

结论

PBM 在每次治疗后可为 BMS 患者提供显著的即刻疼痛缓解;然而,在接下来的一周内,疗效显著下降。随着治疗次数的增加,疼痛缓解呈增加趋势,在第三次治疗时具有统计学意义。

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