Barducci Robson Sfaciotti, Santos Anderson Aparecido Dias, Pacheco Leticia Graziele, Putarov Thaila Cristina, Koch João Fernando Albers, Callegari Marco Aurélio, Dias Cleandro Pazinato, de Carvalho Rafael Humberto, da Silva Caio Abércio
Biorigin, Lençóis Paulista 18680-900, SP, Brazil.
Akei Animal Research, Fartura 18870-970, SP, Brazil.
Animals (Basel). 2024 Feb 16;14(4):631. doi: 10.3390/ani14040631.
The objective of this study was to evaluate the inclusion of the autolyzed yeast (AY) with or without an immunomodulator (1,3/1,6 β-glucans) as a total/partial substitute for blood plasma (BP) in the diet of post-weaning piglets; zootechnical performance, intestinal health and microbiota, immune responses and energy metabolism were assessed. A total of 240 castrated male and female piglets, with a mean age of 22 days and mean initial weight of 5.24 ± 0.82 kg, were randomly divided into blocks of four treatments with 12 replicates. The dietary inclusions were blood plasma (BP), autolyzed yeast (AY), autolyzed yeast + immunomodulator (AYI) and 50% BP and 50% AY (BPAY). In pre-initial phase II (29-35 days), piglets fed AY showed better feed conversion (FCR = 1.358) than the piglets in the BP (1.484), AYI (1.379) and BPAY (1.442) groups, i.e., 8.49% (0.126), 1.52% (0.021) and 4.50% (0.084), respectively ( = 0.0293). In the total period (21-42 days), better FCR was observed in the AYI (1.458) group, i.e., 4.64% (0.071), 1.15% (0.017) and 4.58% (0.070), than in the BP (1.529), AY (1.475) and BPAY (1.528) groups, respectively ( = 0.0150). In piglets fed AY (n = 3) and BPAY (n = 2), there was a reduction in the number of medications, i.e., 82.35% (-14n) and 88.23% (-15n), respectively ( = 0.0001), compared with that in the BP group (n = 17). In the AY group (73.83 mg/dL), AYI group (69.92 mg/dL), and BPAY group (69.58 mg/dL), piglets exhibited increases in triglyceride levels of 79.32%, 69.83%, and 69.00%, respectively, in comparison to those in the BP group, which had triglyceride levels of 41.17 mg/dL ( = 0.0400). The beta-hydroxybutyrate concentration in the AY group (79.96 ng/μL) was lower by 31.95%, 22.64%, and 5.89% compared to the BP group (117.50 ng/μL), AYI group (103.36 ng/μL), and BPAY group (84.67 ng/μL), respectively ( = 0.0072). In the AYI group, there was modulation of the microbiota, with an increase in the relative abundance of bacteria of the genera , and . AY, associated or not associated with an immunomodulator, is a potential substitute for BP in diets for piglets in the nursery phase, with positive effects on immune, metabolic, and intestinal microbial performance.
本研究的目的是评估在断奶仔猪日粮中添加或不添加免疫调节剂（1,3/1,6 β-葡聚糖）的自溶酵母（AY）作为血浆（BP）的全部/部分替代品的效果；评估了动物生产性能、肠道健康与微生物群、免疫反应和能量代谢。总共240头去势的雄性和雌性仔猪，平均年龄22天，平均初始体重5.24±0.82千克，被随机分为4个处理组，每组12个重复。日粮添加物分别为血浆（BP）、自溶酵母（AY）、自溶酵母+免疫调节剂（AYI）以及50%BP和50%AY（BPAY）。在初始期II前期（29 - 35天），饲喂AY的仔猪饲料转化率（FCR = 1.358）优于BP组（1.484）、AYI组（1.379）和BPAY组（1.442）的仔猪，分别提高了8.49%（0.126）、1.52%（0.021）和4.50%（0.084）（P = 0.0293）。在整个时期（21 - 42天），AYI组（1.458）的FCR更佳，分别比BP组（1.529）、AY组（1.475）和BPAY组（1.528）提高了4.64%（0.071）、1.15%（0.017）和4.58%（0.070）（P = 0.0150）。与BP组（n = 17）相比，饲喂AY（n = 3）和BPAY（n = 2）的仔猪用药次数减少，分别减少了82.35%（-14次）和88.23%（-15次）（P = 0.0001）。与甘油三酯水平为41.17毫克/分升的BP组相比，AY组（73.83毫克/分升）、AYI组（69.92毫克/分升）和BPAY组（69.58毫克/分升）仔猪的甘油三酯水平分别升高了79.32%、69.83%和69.00%（P = 0.0400）。与BP组（117.50纳克/微升）、AYI组（103.36纳克/微升）和BPAY组（84.67纳克/微升）相比，AY组（79.96纳克/微升）的β-羟基丁酸浓度分别降低了31.95%、22.64%和5.89%（P = 0.0072）。在AYI组中，微生物群发生了变化，属、属和属细菌的相对丰度增加。AY无论是否与免疫调节剂联用，都是保育期仔猪日粮中BP的潜在替代品，对免疫、代谢和肠道微生物性能有积极影响。
