在健康志愿者中进行的一项安慰剂对照研究，比较哌仑西平和阿米替林对酪胺升压试验的影响。
A placebo controlled comparison of the effects of pirenzepine and amitriptyline on the tyramine pressor test in healthy volunteers.
作者信息
Wilkins M R, Wynne R D, Kendall M J
出版信息
Br J Clin Pharmacol. 1985 Jun;19(6):829-31. doi: 10.1111/j.1365-2125.1985.tb02722.x.
The possibility of an interaction between pirenzepine, an antimuscarinic drug structurally similar to the tricyclic antidepressants, and sympathomimetic agents was investigated in a group of healthy volunteers. The effect of pirenzepine on response to intravenous tyramine was compared with that of placebo and amitriptyline. The mean dose of tyramine required to elevate systolic blood pressure by 30 mm Hg was 5.0 mg (+/- s.d. 0.8) after placebo, 5.1 mg (+/- 1.0) after pirenzepine and 11.3 mg (+/- 1.8) after amitriptyline. These results suggest that pirenzepine will not potentiate the effects of concurrently administered sympathomimetic drugs.
在一组健康志愿者中研究了哌仑西平（一种结构与三环类抗抑郁药相似的抗毒蕈碱药物）与拟交感神经药之间相互作用的可能性。将哌仑西平对静脉注射酪胺反应的影响与安慰剂和阿米替林的影响进行了比较。安慰剂后使收缩压升高30 mmHg所需酪胺的平均剂量为5.0 mg（±标准差0.8），哌仑西平后为5.1 mg（±1.0），阿米替林后为11.3 mg（±1.8）。这些结果表明，哌仑西平不会增强同时给予的拟交感神经药物的作用。
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