帕罗西汀与阿米替林对酪胺升压反应试验影响的比较。
A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test.
作者信息
Hassan S M, Wainscott G, Turner P
出版信息
Br J Clin Pharmacol. 1985 May;19(5):705-6. doi: 10.1111/j.1365-2125.1985.tb02700.x.
Abstract
The effect of single and repeated dosing of paroxetine on the in vivo noradrenaline uptake process, as determined by tyramine pressor response tests, was evaluated in normal healthy subjects. No statistically significant inhibition of the uptake process was observed for paroxetine, nor did it produce sedation or dryness of the mouth, though effects were observed for amitriptyline.
摘要
在正常健康受试者中，通过酪胺升压反应试验评估了帕罗西汀单次给药和重复给药对体内去甲肾上腺素摄取过程的影响。未观察到帕罗西汀对摄取过程有统计学意义的抑制作用，它也未产生镇静或口干现象，不过观察到阿米替林有这些作用。
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