Rice is an important cereal crop worldwide, the growth of which is affected by rice blast disease, caused by the fungal pathogen . As climate change increases the diversity of pathogens, the disease resistance genes ( genes) in plants must be identified. The major blast-resistance genes have been identified in rice varieties; therefore, rice varieties with genes now need to be identified. Because leucine-rich repeat (LRR) domain proteins possess -gene properties, we used bioinformatics analysis to identify the rice candidate LRR domain receptor-like proteins (OsLRR-RLPs). , which contains six LRR domains, showed differences in the DNA sequence, containing 43 single-nucleotide polymorphisms (SNPs) in and subpopulations. The results of the inoculation analysis indicated that varieties with partial deletion of showed susceptibility, whereas varieties with intact showed resistance. The mutant, generated using clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), showed increased pathogen susceptibility, whereas plants overexpressing this gene showed pathogen resistance. These results indicate that confers resistance to rice, and may be useful for breeding resistant cultivars.