National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China.
The Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich NR4 7UH, UK.
Curr Opin Plant Biol. 2021 Aug;62:102030. doi: 10.1016/j.pbi.2021.102030. Epub 2021 Mar 5.
Plants resist attacks by pathogens via innate immune responses, which are initiated by cell surface-localized pattern-recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat containing receptors (NLRs) leading to pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), respectively. Although the two classes of immune receptors involve different activation mechanisms and appear to require different early signalling components, PTI and ETI eventually converge into many similar downstream responses, albeit with distinct amplitudes and dynamics. Increasing evidence suggests the existence of intricate interactions between PRR-mediated and NLR-mediated signalling cascades as well as common signalling components shared by both. Future investigation of the mechanisms underlying signal collaboration between PRR-initiated and NLR-initiated immunity will enable a more complete understanding of the plant immune system. This review discusses recent advances in our understanding of the relationship between the two layers of plant innate immunity.
植物通过先天免疫反应抵抗病原体的攻击，先天免疫反应分别由细胞表面定位的模式识别受体 (PRRs) 和细胞内核苷酸结合域富含亮氨酸重复序列受体 (NLRs) 启动，导致模式触发免疫 (PTI) 和效应物触发免疫 (ETI)。虽然这两类免疫受体涉及不同的激活机制，似乎需要不同的早期信号成分，但 PTI 和 ETI 最终汇聚到许多类似的下游反应中，尽管幅度和动力学不同。越来越多的证据表明 PRR 介导和 NLR 介导的信号级联之间存在复杂的相互作用，以及两者共有的共同信号成分。对 PRR 起始和 NLR 起始免疫之间信号协同作用机制的未来研究将使人们更全面地了解植物免疫系统。本综述讨论了我们对植物先天免疫的两层之间关系的理解的最新进展。
