Chapp Andrew D, Shan Zhiying, Chen Qing-Hui
Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931, USA.
Antioxidants (Basel). 2024 Jan 23;13(2):139. doi: 10.3390/antiox13020139.
Acetic acid is a bioactive short-chain fatty acid produced in large quantities from ethanol metabolism. In this review, we describe how acetic acid/acetate generates oxidative stress, alters the function of pre-sympathetic neurons, and can potentially influence cardiovascular function in both humans and rodents after ethanol consumption. Our recent findings from in vivo and in vitro studies support the notion that administration of acetic acid/acetate generates oxidative stress and increases sympathetic outflow, leading to alterations in arterial blood pressure. Real-time investigation of how ethanol and acetic acid/acetate modulate neural control of cardiovascular function can be conducted by microinjecting compounds into autonomic control centers of the brain and measuring changes in peripheral sympathetic nerve activity and blood pressure in response to these compounds.
乙酸是一种由乙醇代谢大量产生的生物活性短链脂肪酸。在本综述中，我们描述了乙酸/醋酸盐如何产生氧化应激、改变交感神经节前神经元的功能，以及在乙醇摄入后可能如何影响人类和啮齿动物的心血管功能。我们最近的体内和体外研究结果支持了这样一种观点，即给予乙酸/醋酸盐会产生氧化应激并增加交感神经输出，从而导致动脉血压改变。通过将化合物微量注射到大脑的自主控制中心，并测量外周交感神经活动和血压对这些化合物的反应变化，可以实时研究乙醇和乙酸/醋酸盐如何调节心血管功能的神经控制。
Zotero 插件