Trinh Vu Hoang, Nguyen Huu Thang, Sah Dhiraj Kumar, Choi Jin Myung, Yoon Hyun Joong, Park Sang Chul, Jung Yu Seok, Lee Seung-Rock
Department of Biochemistry, Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501190, Republic of Korea.
Department of Oncology, Department of Medical Sciences, Pham Ngoc Thach University of Medicine, Ho Chi Minh City 700000, Vietnam.
Antioxidants (Basel). 2024 Feb 4;13(2):199. doi: 10.3390/antiox13020199.
Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In addition, PTEN plays an essential role in other physiological events associated with cell growth demands, such as ischemia-reperfusion, nerve injury, and immune responsiveness. Therefore, recently, PTEN inhibition has emerged as a potential therapeutic intervention in these situations. Increasing evidence demonstrates that reactive oxygen species (ROS), especially hydrogen peroxide (HO), are produced and required for the signaling in many important cellular processes under such physiological conditions. ROS have been shown to oxidize PTEN at the cysteine residue of its active site, consequently inhibiting its function. Herein, we provide an overview of studies that highlight the role of the oxidative inhibition of PTEN in physiological processes.
磷酸酶和张力蛋白同源物（PTEN）是一种肿瘤抑制因子，因为它能够通过下调PI3K/AKT信号通路来调节细胞存活、生长和增殖。此外，PTEN在与细胞生长需求相关的其他生理过程中也起着至关重要的作用，如缺血再灌注、神经损伤和免疫反应。因此，最近，PTEN抑制已成为这些情况下潜在的治疗干预手段。越来越多的证据表明，在这种生理条件下，活性氧（ROS），尤其是过氧化氢（H₂O₂），在许多重要的细胞过程的信号传导中产生并发挥作用。ROS已被证明可在PTEN活性位点的半胱氨酸残基处将其氧化，从而抑制其功能。在此，我们概述了一些研究，这些研究突出了PTEN氧化抑制在生理过程中的作用。
