Sundi Debasish, Collier Katharine A, Yang Yuanquan, Diaz Dayssy Alexandra, Pohar Kamal S, Singer Eric A, Gupta Sanjay, Carson William E, Clinton Steven K, Li Zihai, Messing Edward M
Department of Urology, Division of Urologic Oncology, Pelotonia Institute for Immuno-Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Department of Internal Medicine, Division of Medical Oncology, Pelotonia Institute for Immuno-Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Cancers (Basel). 2024 Feb 10;16(4):746. doi: 10.3390/cancers16040746.
Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.
临床前和临床数据表明，雄激素受体信号传导在膀胱癌发展中起重要作用。雄激素受体在膀胱致癌作用中的角色对于理解该疾病中强烈的男性性别偏向以及潜在治疗策略具有明显意义。在本综述中，我们总结了关于尿路上皮癌以及肿瘤浸润免疫细胞中雄激素受体信号传导的已知信息，回顾了临床前和临床数据。我们还强调了该领域的临床试验进展。
