Popescu Daniela Eugenia, Jura Ana Maria Cristina, Știube Dana, Ciulpan Adrian, Stoica Florina, Șipoș Simona Ioana, Cîtu Cosmin, Gorun Florin, Boia Mărioara
Department of Obstetrics and Gynecology, "Victor Babeş" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania.
Department of Neonatology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No. 113, 300645 Timisoara, Romania.
Life (Basel). 2024 Feb 5;14(2):224. doi: 10.3390/life14020224.
During the last decades, a growing number of studies have shown that infections during pregnancy have an important impact on both pregnant women and their fetuses. Our goal was to include newborns from pregnancies with SARS-CoV-2 infection and to investigate the extension of neonatal complications using cardiac, abdominal, and cerebral ultrasonography; hearing testing; and indirect ophthalmoscopy. Likewise, neonates whose mothers were vaccinated against COVID-19 during pregnancy and those from pathology-free pregnancies were examined. A total of 458 mother-newborn dyads were included over a period of 10 months and divided into three groups: the COVID-19 group, vaccine group, and control group. Although six cardiac malformations were found in the COVID-19 group, no correlation was made compared to the vaccine and control group ( = 0.07). Grade 1 intraventricular hemorrhage and hypoxic ischemic encephalopathy were the most prevalent among neonates from mothers with SARS-CoV-2 infection ( = 0.002 and < 0.001, respectively). The kidney anomaly found to be most frequent in this group was grade 1 unilateral hydronephrosis ( < 0.001). COVID-19 disease during the gestational period had no effect on the auditory or visual function. Our findings highlight the importance of implementing proper infection control practices for future mothers, and by continuing to investigate this topic, we can gather valuable insights that will improve neonatal health in this context.
在过去几十年中，越来越多的研究表明，孕期感染对孕妇及其胎儿均有重要影响。我们的目标是纳入感染了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的孕妇所生的新生儿，并通过心脏、腹部和脑部超声检查、听力测试以及间接检眼镜检查来调查新生儿并发症的情况。同样，对孕期接种了2019冠状病毒病（COVID-19）疫苗的母亲所生的新生儿以及来自无病理妊娠的新生儿进行了检查。在10个月的时间里，共纳入了458对母婴，并将其分为三组：COVID-19组、疫苗组和对照组。尽管在COVID-19组中发现了6例心脏畸形，但与疫苗组和对照组相比，未发现相关性（P = 0.07）。1级脑室内出血和缺氧缺血性脑病在感染SARS-CoV-2的母亲所生的新生儿中最为常见（分别为P = 0.002和P < 0.001）。该组中最常见的肾脏异常是1级单侧肾积水（P < 0.001）。孕期的COVID-19疾病对听觉或视觉功能没有影响。我们的研究结果强调了对未来母亲实施适当感染控制措施的重要性，并且通过继续研究这个话题，我们可以收集有价值的见解，从而在这种情况下改善新生儿健康。
