Department of Cardiovascular Surgery, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Medicina (Kaunas). 2024 Feb 8;60(2):290. doi: 10.3390/medicina60020290.
Venous aneurysms are rare vascular malformations that can lead to significant clinical complications, including thrombosis, pulmonary embolism, rupture, and even fatal outcomes when not promptly and adequately managed. This case report presents a liver transplant patient under immunosuppressive therapy who developed a rapidly progressing great saphenous vein aneurysm, ultimately requiring urgent surgical intervention due to acute bleeding from the ruptured aneurysm. Immunosuppression emerges as a potential key factor in the formation and rapid growth of the aneurysm, with the pathophysiological mechanism potentially involving increased expression of specific matrix metalloproteinases. Further research is warranted to gain a better understanding of the role of immunosuppression in the development of venous aneurysms.
静脉瘤是一种罕见的血管畸形，如果不能及时、充分地治疗，可能会导致严重的临床并发症，包括血栓形成、肺栓塞、破裂，甚至导致致命后果。本病例报告介绍了一位接受免疫抑制治疗的肝移植患者，他出现了迅速进展的大隐静脉瘤，最终由于破裂的动脉瘤急性出血，需要紧急手术干预。免疫抑制被认为是动脉瘤形成和快速生长的一个潜在关键因素，其病理生理学机制可能涉及特定基质金属蛋白酶表达增加。需要进一步的研究来更好地了解免疫抑制在静脉瘤形成中的作用。
