Multilevel Venous Obstruction in Patients with Cardiac Implantable Electronic Devices.

: The nature of multilevel lead-related venous stenosis/occlusion (MLVSO) and its influence on transvenous lead extraction (TLE) as well as long-term survival remains poorly understood. : A total of 3002 venograms obtained before a TLE were analyzed to identify the risk factors for MLVSO, as well as the procedure effectiveness and long-term survival. : An older patient age at the first system implantation (OR = 1.015; < 0.001), the number of leads in the heart (OR = 1.556; < 0.001), the placement of the coronary sinus (CS) lead (OR = 1.270; = 0.027), leads on both sides of the chest (OR = 7.203; < 0.001), and a previous device upgrade or downgrade with lead abandonment (OR = 2.298; < 0.001) were the strongest predictors of MLVSO. : The presence of MLVSO predisposes patients with cardiac implantable electronic devices (CIED) to the development of infectious complications. Patients with multiple narrowed veins are likely to undergo longer and more complex procedures with complications, and the rates of clinical and procedural success are lower in this group. Long-term survival after a TLE is similar in patients with MLVSO and those without venous obstruction. MLVSO probably better depicts the severity of global venous obstruction than the degree of vein narrowing at only one point.