Department of Anaesthesia and Intensive Care, Copenhagen University Hospital-Bispebjerg and Frederiksberg, DK-2400 Copenhagen, Denmark.
Center for Cancer and Organ Diseases, Department of Anaesthesia, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark.
Sensors (Basel). 2024 Feb 9;24(4):1139. doi: 10.3390/s24041139.
The monitoring of oxygen therapy when patients are admitted to medical and surgical wards could be important because exposure to excessive oxygen administration (EOA) may have fatal consequences. We aimed to investigate the association between EOA, monitored by wireless pulse oximeter, and nonfatal serious adverse events (SAEs) and mortality within 30 days. We included patients in the Capital Region of Copenhagen between 2017 and 2018. Patients were hospitalized due to acute exacerbation of chronic obstructive pulmonary disease (AECOPD) or after major elective abdominal cancer surgery, and all were treated with oxygen supply. Patients were divided into groups by their exposure to EOA: no exposure, exposure for 1-59 min or exposure over 60 min. The primary outcome was SAEs or mortality within 30 days. We retrieved data from 567 patients for a total of 43,833 h, of whom, 63% were not exposed to EOA, 26% had EOA for 1-59 min and 11% had EOA for ≥60 min. Nonfatal SAEs or mortality within 30 days developed in 24%, 12% and 22%, respectively, and the adjusted odds ratio for this was 0.98 (95% CI, 0.96-1.01) for every 10 min. increase in EOA, without any subgroup effects. In conclusion, we did not observe higher frequencies of nonfatal SAEs or mortality within 30 days in patients exposed to excessive oxygen administration.
当患者入住内科和外科病房时，对氧疗的监测可能很重要，因为暴露于过度供氧（EOA）可能会产生致命后果。我们旨在研究通过无线脉搏血氧仪监测的 EOA 与 30 天内非致命性严重不良事件（SAE）和死亡率之间的关联。我们纳入了 2017 年至 2018 年哥本哈根首都大区的患者。患者因慢性阻塞性肺疾病急性加重（AECOPD）或择期大腹部癌症手术后住院，所有患者均接受供氧治疗。患者根据其 EOA 暴露情况分为无暴露、暴露 1-59 分钟或暴露超过 60 分钟组。主要结局为 30 天内 SAE 或死亡率。我们从 567 名患者中检索了共 43833 小时的数据，其中 63%的患者未暴露于 EOA，26%的患者 EOA 暴露 1-59 分钟，11%的患者 EOA 暴露时间≥60 分钟。30 天内分别有 24%、12%和 22%发生非致命性 SAE 或死亡，调整后的比值比（OR）为每增加 10 分钟 EOA，风险增加 0.98（95%CI，0.96-1.01），无亚组效应。总之，我们未观察到暴露于过度供氧的患者在 30 天内发生非致命性 SAE 或死亡率的频率更高。
