Masuoka Shotaro, Nishio Junko, Yamada Soichi, Saito Kosuke, Kaneko Kaichi, Kaburaki Makoto, Tanaka Nahoko, Sato Hiroshi, Muraoka Sei, Kawazoe Mai, Mizutani Satoshi, Furukawa Karin, Ishii-Watabe Akiko, Kawai Shinichi, Saito Yoshiro, Nanki Toshihiro
Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo, 143-8541, Japan.
Department of Immunopathology and Immunoregulation, Toho University School of Medicine, Tokyo, Japan.
Inflammation. 2024 Aug;47(4):1444-1458. doi: 10.1007/s10753-024-01986-8. Epub 2024 Feb 24.
Lipid mediators have been suggested to play important roles in the pathogenesis of rheumatoid arthritis (RA). Lipidomics has recently allowed for the comprehensive analysis of lipids and has revealed the potential of lipids as biomarkers for the early diagnosis of RA and prediction of therapeutic responses. However, the relationship between disease activity and the lipid profile in RA remains unclear. In the present study, we performed a plasma lipidomic analysis of 278 patients with RA during treatment and examined relationships with disease activity using the Disease Activity Score in 28 joints (DAS28)-erythrocyte sedimentation rate (ESR). In all patients, five lipids positively correlated and seven lipids negatively correlated with DAS28-ESR. Stearic acid [FA(18:0)] (r = -0.45) and palmitic acid [FA(16:0)] (r = -0.38) showed strong negative correlations. After adjustments for age, body mass index (BMI), and medications, stearic acid, palmitic acid, bilirubin, and lysophosphatidylcholines negatively correlated with disease activity. Stearic acid inhibited osteoclast differentiation from peripheral blood monocytes in in vitro experiments, suggesting its contribution to RA disease activity by affecting bone metabolism. These results indicate that the lipid profile correlates with the disease activity of RA and also that some lipids may be involved in the pathogenesis of RA.
脂质介质被认为在类风湿关节炎（RA）的发病机制中起重要作用。脂质组学最近使得对脂质进行全面分析成为可能，并揭示了脂质作为RA早期诊断生物标志物和治疗反应预测指标的潜力。然而，RA中疾病活动与脂质谱之间的关系仍不清楚。在本研究中，我们对278例正在接受治疗的RA患者进行了血浆脂质组学分析，并使用28个关节疾病活动评分（DAS28）-红细胞沉降率（ESR）来检查与疾病活动的关系。在所有患者中，5种脂质与DAS28-ESR呈正相关，7种脂质呈负相关。硬脂酸[FA(18:0)]（r = -0.45）和棕榈酸[FA(16:0)]（r = -0.38）显示出强烈的负相关。在对年龄、体重指数（BMI）和药物进行校正后，硬脂酸、棕榈酸、胆红素和溶血磷脂酰胆碱与疾病活动呈负相关。在体外实验中，硬脂酸抑制外周血单核细胞向破骨细胞的分化，提示其通过影响骨代谢对RA疾病活动有贡献。这些结果表明脂质谱与RA的疾病活动相关，并且一些脂质可能参与了RA的发病机制。
