College of Mechanical Engineering, Inner Mongolia University of Technology, Hohhot 010000, PR China.
School of Materials Science and Engineering, Inner Mongolia University of Technology, Hohhot 010051, PR China.
Comput Methods Programs Biomed. 2024 Apr;247:108094. doi: 10.1016/j.cmpb.2024.108094. Epub 2024 Feb 18.
The lower extremity movement involves a complex and large amplitude extremity movement process, and arterial stents implanted in the lower extremity are prone to complex mechanical deformation behavior. Hence, the lower extremity arterial stent is required to have favorable comprehensive mechanical properties.
In this study, a new lower extremity arterial stent (New) was proposed, and its deformation behavior and mechanical properties were analyzed by numerical simulations under different deformation modes, such as radial compression, axial compression/tension, bending, and torsion. Stents with different diameters were modeled to compare the effect of diameter size on their biomechanical properties. Additionally, a comparative analysis was conducted between this new stent and seven commercially available stents.
The results demonstrated that the stent diameter exerted a significant effect on its deformation behavior and mechanical properties. Specifically, with the increase of the stent diameter, the radial expansion rate, radial shrinkage rate, radial support stiffness, axial compression stiffness, and axial tensile stiffness tended to decrease, and the expansion inhomogeneity, stenosis rate, bending stiffness, and torsional stiffness tended to increase. In contrast, the stent diameter exerted a small effect on the stent axial shortening rate and ellipticity. The new lower extremity arterial stent was validated to outperform other stents in terms of most performance indicators. Especially, the radial expansion rate and ellipticity of the New stent were better than those of all commercially available stents. Moreover, the New stent presented favorable mechanical properties and flexibility under the premise of ensuring the support performance.
Based on these findings, this lower extremity arterial stent may play a better therapeutic effect in clinical application. Furthermore, these analysis results may provide reference for the clinical application and selection of the stent.
下肢运动涉及复杂且大振幅的肢体运动过程，植入下肢的动脉支架容易产生复杂的力学变形行为。因此，下肢动脉支架需要具有良好的综合力学性能。
本研究提出了一种新型下肢动脉支架（New），通过数值模拟分析了其在不同变形模式下的变形行为和力学性能，如径向压缩、轴向压缩/拉伸、弯曲和扭转。建立了不同直径的支架模型，以比较直径大小对其生物力学性能的影响。此外，还对这种新型支架和七种市售支架进行了对比分析。
结果表明，支架直径对其变形行为和力学性能有显著影响。具体而言，随着支架直径的增加，径向扩张率、径向收缩率、径向支撑刚度、轴向压缩刚度和轴向拉伸刚度趋于减小，扩张不均匀度、狭窄率、弯曲刚度和扭转刚度趋于增加。相比之下，支架直径对支架轴向缩短率和椭圆度的影响较小。新型下肢动脉支架在大多数性能指标上均优于其他支架。特别是，New 支架的径向扩张率和椭圆度优于所有市售支架。此外，在保证支撑性能的前提下，New 支架具有良好的力学性能和柔韧性。
基于这些发现，这种下肢动脉支架在临床应用中可能会产生更好的治疗效果。此外，这些分析结果可为支架的临床应用和选择提供参考。
