Zhai Yun, Sun Zezhi, Zhang Tie, Zhou Changchun, Kong Xiangpeng
School of Mechanical Engineering, Dalian Jiaotong University, Dalian 116028, China.
National Engineering Research Centre for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
Micromachines (Basel). 2024 Oct 17;15(10):1266. doi: 10.3390/mi15101266.
Vascular stents have many applications in treating arterial stenosis and other vascular-related diseases. The ideal vascular stent for clinical application should have radial support and axial bending mechanical properties that meet the requirements of vascular deformation coordination. The materials used for vascular stents implanted in the human body should have corresponding biocompatibility to ensure that the stents do not cause coagulation, hemolysis, and other reactions in the blood. This study fabricated four types of vascular stents, including inner hexagon, arrowhead, quadrilateral, and outer hexagonal, using fused filament fabrication technology and thermoplastic polyurethane (TPU) as materials. By evaluating the effects of edge width and wall thickness on the radial support and axial bending performance, it was found that the inner hexagonal stent exhibited the best radial support and axial bending performance under the same conditions. The design and fabrication of vascular stents based on 3D printing technology have promising application prospects in personalized customized vascular repair therapy.
血管支架在治疗动脉狭窄和其他血管相关疾病方面有许多应用。临床应用中理想的血管支架应具有满足血管变形协调要求的径向支撑和轴向弯曲力学性能。植入人体的血管支架所用材料应具有相应的生物相容性，以确保支架在血液中不会引起凝血、溶血等反应。本研究采用熔融沉积成型技术，以热塑性聚氨酯（TPU）为材料，制作了内六边形、箭头形、四边形和外六边形四种类型的血管支架。通过评估边缘宽度和壁厚对径向支撑和轴向弯曲性能的影响，发现内六边形支架在相同条件下表现出最佳的径向支撑和轴向弯曲性能。基于3D打印技术的血管支架设计与制造在个性化定制血管修复治疗中具有广阔的应用前景。
