Kitahara M, Ishii K, Kawaharada H, Watanabe K, Suga T, Hirata T, Nakamura S
J Antibiot (Tokyo). 1985 Aug;38(8):977-80. doi: 10.7164/antibiotics.38.977.
The molecular formula of a new antimetabolite produced by Streptomyces purpurascens was determined to be C5H5N5O2 by elemental analysis, FD-MS and 13C NMR. Reduction of this antimetabolite with Raney nickel yielded guanine. The antimetabolite was distinguishable from known N-hydroxyguanines by comparison of their UV spectra. The structure of the antimetabolite was finally established to be 7-hydroxyguanine by X-ray crystallography.
通过元素分析、场解吸质谱（FD-MS）和碳-13核磁共振（13C NMR）确定，由紫色链霉菌产生的一种新抗代谢物的分子式为C5H5N5O2。用雷尼镍还原这种抗代谢物可得到鸟嘌呤。通过比较其紫外光谱，该抗代谢物与已知的N-羟基鸟嘌呤可区分开来。最终通过X射线晶体学确定该抗代谢物的结构为7-羟基鸟嘌呤。
