Edwards D K, Hilton S V, Merritt T A, Hallman M, Mannino F, Boynton B R
Radiology. 1985 Nov;157(2):329-34. doi: 10.1148/radiology.157.2.3840268.
Chest radiographs of 18 newborns treated with endotracheal instillation of human surfactant for respiratory distress syndrome (RDS) were compared with those of 18 similar but untreated infants. In the treated infants, severity of RDS significantly improved after surfactant administration. Most treated infants (16/18) exhibited a left-to-right shunt, presumably through a patent ductus arteriosus; similar findings were noted in untreated infants (17/18). Complications of respiratory assistance in the treated infants included transient pulmonary interstitial emphysema (n = 1), pneumothorax (n = 1), and mild (n = 4) to moderate (n = 2) bronchopulmonary dysplasia; the incidences of these complications did not exceed those in untreated infants. In three treated infants, a transient interstitial lung disease developed 3-4 days after surfactant administration.
对18例因呼吸窘迫综合征（RDS）接受气管内滴注人肺表面活性物质治疗的新生儿的胸部X线片与18例相似但未治疗的婴儿的胸部X线片进行了比较。在接受治疗的婴儿中，肺表面活性物质给药后RDS的严重程度显著改善。大多数接受治疗的婴儿（16/18）出现了左向右分流，推测是通过动脉导管未闭；未治疗的婴儿中也观察到了类似的结果（17/18）。接受治疗的婴儿呼吸辅助的并发症包括短暂性肺间质肺气肿（n = 1）、气胸（n = 1）以及轻度（n = 4）至中度（n = 2）支气管肺发育不良；这些并发症的发生率未超过未治疗婴儿。在3例接受治疗的婴儿中，肺表面活性物质给药后3 - 4天出现了短暂性间质性肺病。
