Guangzhou Key Laboratory of Formula-Pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
Pharmacol Res. 2024 Apr;202:107112. doi: 10.1016/j.phrs.2024.107112. Epub 2024 Feb 23.
Depression is a common disease that affects physical and mental health and imposes a considerable burden on afflicted individuals and their families worldwide. Depression is associated with a high rate of disability and suicide. It causes a severe decline in productivity and quality of life. Unfortunately, the pathophysiological mechanisms underlying depression have not been fully elucidated, and the risk of its treatment is still presented. Studies have shown that the expression of autophagic markers in the brain and peripheral inflammatory mediators are dysregulated in depression. Autophagy-related genes regulate the level of autophagy and change the inflammatory response in depression. Depression is related to several aspects of immunity. The regulation of the immune system and inflammation by autophagy may lead to the development or deterioration of mental disorders. This review highlights the role of autophagy and neuroinflammation in the pathophysiology of depression, sumaries the autophagy-targeting small moleculars, and discusses a novel therapeutic strategy based on anti-inflammatory mechanisms that target autophagy to treat the disease.
抑郁症是一种常见的疾病，影响身心健康，给全球患者及其家庭带来了巨大负担。抑郁症与高残疾率和自杀率有关。它导致生产力和生活质量的严重下降。不幸的是，抑郁症的病理生理机制尚未完全阐明，其治疗风险仍然存在。研究表明，抑郁症患者大脑中的自噬标志物和外周炎症介质的表达失调。自噬相关基因调节自噬水平，并改变抑郁症中的炎症反应。抑郁症与免疫的几个方面有关。自噬对免疫系统和炎症的调节可能导致精神障碍的发展或恶化。本综述强调了自噬和神经炎症在抑郁症发病机制中的作用，总结了自噬靶向小分子，并讨论了一种基于抗炎机制的新型治疗策略，该策略靶向自噬治疗疾病。
