褪黑素及其受体对自噬的调节作用：对脑部疾病的影响
Modulation of autophagy by melatonin and its receptors: implications in brain disorders.
作者信息
Zhu Chen-Ze, Li Gui-Zhi, Lyu Hai-Feng, Lu Yang-Yang, Li Yue, Zhang Xiang-Nan
机构信息
Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang University, Hangzhou, 310058, China.
School of Pharmacy, Hangzhou Medical College, Hangzhou, 311399, China.
出版信息
Acta Pharmacol Sin. 2025 Mar;46(3):525-538. doi: 10.1038/s41401-024-01398-2. Epub 2024 Oct 24.
Abstract
Autophagy plays a crucial role in maintaining neuronal homeostasis and function, and its disruption is linked to various brain diseases. Melatonin, an endogenous hormone that primarily acts through MT1 and MT2 receptors, regulates autophagy via multiple pathways. Growing evidence indicates that melatonin's ability to modulate autophagy provides therapeutic and preventive benefits in brain disorders, including neurodegenerative and affective diseases. In this review, we summarize the key mechanisms by which melatonin affects autophagy and explore its therapeutic potential in the treatment of brain disorders.
摘要
自噬在维持神经元稳态和功能方面发挥着关键作用，其破坏与多种脑部疾病相关。褪黑素是一种主要通过MT1和MT2受体起作用的内源性激素，它通过多种途径调节自噬。越来越多的证据表明，褪黑素调节自噬的能力在脑部疾病（包括神经退行性疾病和情感性疾病）中具有治疗和预防作用。在这篇综述中，我们总结了褪黑素影响自噬的关键机制，并探讨了其在脑部疾病治疗中的潜在治疗价值。
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