Ma Ding-Cai, Wang Zhe, Wang Mao-Mao, Zhang Yu-Gui, Wang Yan-Jun, Liu Ting, Zhang Zhuan-Hong, Gao Fei-Yun, Li Yue-Feng
Gansu University of Chinese Medicine Lanzhou 730000, China Gansu Provincial Key Laboratory for Research on Quality and Standards of Chinese Medicine Lanzhou 730000, China.
Zhongguo Zhong Yao Za Zhi. 2024 Jan;49(2):294-303. doi: 10.19540/j.cnki.cjcmm.20231106.601.
Lung cancer is the leading cause of cancer death, and its effective treatment is a difficult medical problem. Lung cancer belongs to the traditional Chinese medicine(TCM) disease categories of lung accumulation, lung amassment, and overstrain cough. Rich theoretical basis and practical experience have been accumulated in the TCM treatment of lung cancer. Astragali Radix is one of the representatives of Qi-tonifying drugs. It mainly treat the lung cancer with the syndrome of Qi deficiency and pathogen stagnation, following the principle of reinforcing healthy Qi and eliminating patgogenic Qi. Astragali Radix exerts a variety of pharmacological activities in the treatment of lung cancer, including inhibiting tumor cell proliferation and promoting tumor cell apoptosis, inhibiting tumor invasion and migration, regulating the tumor microenvironment, suppressing tumor angiogenesis, modulating autophagy, inducing macrophage polarization, enhancing immunity, inhibiting immune escape, and reversing cisplatin resistance. The active ingredients of Astragali Radix in treating lung cancer include polysaccharides, saponins, and flavonoids. This study reviewed the pharmacological activities and active ingredients of Astragali Radix in the treatment of lung cancer, providing a basis for the development and utilization of Astragali Radix resources and active ingredients and the research and development of anti-tumor drugs.
肺癌是癌症死亡的主要原因，其有效治疗是一个棘手的医学难题。肺癌属于中医“肺积”“肺痞”“劳嗽”等病症范畴。中医在肺癌治疗方面积累了丰富的理论基础和实践经验。黄芪是补气药的代表之一。它主要用于治疗气虚邪滞型肺癌，遵循扶正祛邪的原则。黄芪在肺癌治疗中发挥多种药理活性，包括抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、抑制肿瘤侵袭和迁移、调节肿瘤微环境、抑制肿瘤血管生成、调节自噬、诱导巨噬细胞极化、增强免疫力、抑制免疫逃逸以及逆转顺铂耐药性。黄芪治疗肺癌的活性成分包括多糖、皂苷和黄酮类化合物。本研究综述了黄芪在肺癌治疗中的药理活性和活性成分，为黄芪资源及活性成分的开发利用以及抗肿瘤药物的研发提供依据。
