Lu Ling-Jing, Zhang Jiao, Jiang Yue, Han Yan-Hua, Zhang Yue-Hui
Heilongjiang University of Chinese Medicine Harbin 150040, China.
Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Harbin 150001, China.
Zhongguo Zhong Yao Za Zhi. 2024 Jan;49(1):1-14. doi: 10.19540/j.cnki.cjcmm.20231018.601.
Polycystic ovary syndrome(PCOS) is a highly prevalent endocrine and reproductive disorder characterized by ovulatory dysfunction, hyperandrogenism(HA), and polycystic ovarian morphology(PCOM). It is often accompanied by insulin resistance(IR), obesity, and metabolic disorders and can lead to cardiovascular diseases, endometrial carcinoma and many other late complications, seriously affecting the physical and mental health and quality of life in premenopausal women. The etiology of PCOS is still unknown and many scholars assume that mitochondrial dysfunction may represent a major pathogenic factor in PCOS in recent years. With a holistic view, treatment based on syndrome differentiation, and multi-system and multi-target treatment manner, traditional Chinese medicine(TCM) can mitigate the symptoms and signs of PCOS from multiple aspects. Although there have been reviews on the mechanism of mitochondrial dysfunction in PCOS, there is still a lack of reviews on the intervention of mitochondrial function by TCM to treat PCOS. Therefore, this paper focuses on the role of mitochondrial dysfunction in PCOS and summarizes the studies about the TCM intervention of PCOS by regulating the mitochondrial function, inflammation, oxidative stress(OS), autophagy, and apoptosis in the last five years, aiming to shed new light on the prevention and treatment of PCOS with TCM.
多囊卵巢综合征（PCOS）是一种高度常见的内分泌和生殖紊乱疾病，其特征为排卵功能障碍、高雄激素血症（HA）和多囊卵巢形态（PCOM）。它常伴有胰岛素抵抗（IR）、肥胖和代谢紊乱，并可导致心血管疾病、子宫内膜癌和许多其他晚期并发症，严重影响绝经前女性的身心健康和生活质量。PCOS的病因尚不清楚，近年来许多学者认为线粒体功能障碍可能是PCOS的一个主要致病因素。中医以整体观、辨证论治以及多系统、多靶点的治疗方式，可从多个方面减轻PCOS的症状和体征。虽然已有关于PCOS中线粒体功能障碍机制的综述，但仍缺乏关于中医干预线粒体功能治疗PCOS的综述。因此，本文聚焦线粒体功能障碍在PCOS中的作用，总结近五年来中医通过调节线粒体功能、炎症、氧化应激（OS）、自噬和凋亡干预PCOS的研究，旨在为中医防治PCOS提供新的思路。
