Rodenburg C J, Nieuwenhuyzen Kruseman A C, de Maaker H A, Fleuren G J, van Oosterom A T
Arch Pathol Lab Med. 1985 Nov;109(11):1046-8.
We describe a patient with advanced bladder carcinoma, in which ectopic synthesis and secretion of human chorionic gonadotropinlike immunoreactivity (ihCG) was demonstrated. Concanavalin A-sepharose affinity chromatography of serum revealed that the ihCG differed from placental human chorionic gonadotropin in its carbohydrate moiety. Treatment of the patient with a cisplatin-containing regimen did not result in regression of the tumor. Since immunohistochemistry revealed ihCG in five of 13 additional cases of bladder carcinoma, it is concluded that ectopic production of ihCG by bladder carcinomas is probably not rare.
我们描述了一名晚期膀胱癌患者，该患者体内证实有人绒毛膜促性腺激素样免疫反应性（ihCG）的异位合成与分泌。血清的伴刀豆球蛋白A-琼脂糖亲和层析显示，ihCG在碳水化合物部分与胎盘人绒毛膜促性腺激素不同。用含顺铂的方案治疗该患者并未使肿瘤消退。由于免疫组织化学在另外13例膀胱癌病例中的5例中发现了ihCG，因此得出结论，膀胱癌异位产生ihCG可能并不罕见。
