Oyasu R, Nan L, Smith D P, Kawamata H
Department of Pathology, Northwestern University Medical School, Chicago, Ill 60611-3008.
Arch Pathol Lab Med. 1994 Jul;118(7):715-7.
An undifferentiated deeply invasive ureteral carcinoma with syncytiotrophoblastic differentiation was analyzed for the synthesis of human chorionic gonadotropin beta-subunit by immunohistochemistry and Northern blot analysis. Human chorionic gonadotropin beta-subunit was localized immunohistochemically to syncytiotrophoblastic cells and scattered mononuclear tumor cells. Human chorionic gonadotropin beta-subunit gene was expressed at a high level by Northern blot analysis. To our knowledge, this is the first report demonstrating the synthesis of human chorionic gonadotropin beta-subunit at the transcriptional level in a urothelial carcinoma.
对一例具有合体滋养层细胞分化的未分化浸润性输尿管癌进行免疫组织化学和Northern印迹分析，以检测人绒毛膜促性腺激素β亚基的合成情况。免疫组织化学显示，人绒毛膜促性腺激素β亚基定位于合体滋养层细胞和散在的单核肿瘤细胞。Northern印迹分析表明，人绒毛膜促性腺激素β亚基基因高水平表达。据我们所知，这是首次报道在尿路上皮癌中从转录水平证实人绒毛膜促性腺激素β亚基的合成。
