Law S W, Lee N, Monge J C, Brewer H B, Sakaguchi A Y, Naylor S L
Biochem Biophys Res Commun. 1985 Sep 16;131(2):1003-12. doi: 10.1016/0006-291x(85)91339-7.
Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23----pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23----pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23----pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19.
人载脂蛋白（apo）B - 100是低密度脂蛋白（LDL）的主要载脂蛋白，也是与LDL受体相互作用的主要配体。通过用放射性标记的apoB - 100 cDNA探针以及含有2号染色体易位的人 - 鼠体细胞杂种进行滤膜杂交分析，已将apoB - 100基因定位于2号染色体的p23----pter区域。2号染色体短臂末端的其他基因包括酸性磷酸酶、阿片促黑激素皮质素原复合物、苹果酸脱氢酶和N - myc，后者基因先前已定位于与apoB - 100基因相同的带区（2p23----pter）。将apoB - 100基因定位于2号染色体的p23----pter区域，完善了LDL受体以及LDL受体的两种载脂蛋白配体apoE和apoB - 100的基因组组织关系；LDL受体和apoE先前已定位于19号染色体。
