School of Textile Science and Engineering, Key Laboratory of Functional Textile Material and Product of the Ministry of Education, Xi'an Polytechnic University, Xi'an, Shaanxi, 710048, China.
State Key Laboratory of Solidification Processing, Center of Advanced Lubrication and Seal Materials, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an, 710072, China.
Adv Mater. 2024 Jun;36(23):e2308748. doi: 10.1002/adma.202308748. Epub 2024 Mar 9.
Bone implants for different body parts require varying mechanical properties, dimensions, and biodegradability rates. Currently, it is still challenging to produce artificial bones with perfect compatibility with human bones. In this study, a silk-fabric reinforced silk material (SFS) composed of pure silk with exceptional biocompatibility, osteogenesis, and biodegradability is reported, and demonstrates its outstanding performance as a bone implant material. The SFS is fabricated using a simple hot-pressing technique, with degummed silk fabric as the reinforcement and silk fibroin as the matrix. The SFS as a self-reinforced composite, has exceptional mechanical properties due to the almost perfect interface between the matrix and reinforcement. More importantly, its mechanical properties, biodegradability rates, and density can be tailored by adjusting the reinforcement structure and the ratio of the reinforcement to the matrix to align with the requirements for bone implantation in different parts of the human body. Besides, the SFS can improve osteoblastic proliferation and increase osteogenic activity, which is not the case with clinically used titanium alloy artificial bone. Therefore, the SFS holds significant potential to replace conventional metal or ceramic implants in the field of medical fracture repair.
用于不同身体部位的骨植入物需要具有不同的机械性能、尺寸和可生物降解性。目前，生产与人体骨骼完美兼容的人工骨仍然具有挑战性。在这项研究中，报告了一种由具有优异的生物相容性、成骨和可生物降解性的纯丝组成的丝织物增强丝材料 (SFS)，并展示了其作为骨植入物材料的出色性能。SFS 是使用简单的热压技术制造的，脱胶丝织物作为增强体，丝素蛋白作为基体。SFS 作为一种自增强复合材料，由于基体和增强体之间几乎完美的界面，具有优异的机械性能。更重要的是，通过调整增强结构和增强体与基体的比例，可以调整其机械性能、可生物降解性和密度，以满足人体不同部位骨植入的要求。此外，SFS 可以促进成骨细胞增殖并增加成骨活性，而这在临床上使用的钛合金人工骨中并不常见。因此，SFS 有可能取代传统的金属或陶瓷植入物，在医学骨折修复领域具有重要的应用潜力。
