Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Key Laboratory of Cluster Science of Ministry of Education, Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion Materials, School of Medical Technology, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, P. R. China.
Biomater Sci. 2024 Mar 26;12(7):1630-1642. doi: 10.1039/d3bm02026f.
To meet the demand for precision medicine, researchers are committed to developing novel strategies to reduce systemic toxicity and side effects in cancer treatment. Targeting peptides are widely applied due to their affinity and specificity, and their ability to be high-throughput screened, chemically synthesized and modified. More importantly, peptides can form ordered self-assembled structures through non-covalent supramolecular interactions, which can form nanostructures with different morphologies and functions, playing crucial roles in targeted diagnosis and treatment. Among them, in targeted immunotherapy, utilizing targeting peptides to block the binding between immune checkpoints and ligands, thereby activating the immune system to eliminate cancer cells, is an advanced therapeutic strategy. In this mini-review, we summarize the screening, self-assembly, and biomedical applications of targeting peptide-based nanomaterials. Furthermore, this mini-review summarizes the potential and optimization strategies of targeting peptides.
为了满足精准医学的需求，研究人员致力于开发新的策略来降低癌症治疗中的全身毒性和副作用。由于靶向肽具有亲和力和特异性，并且能够进行高通量筛选、化学合成和修饰，因此被广泛应用。更重要的是，肽可以通过非共价超分子相互作用形成有序的自组装结构，从而形成具有不同形态和功能的纳米结构，在靶向诊断和治疗中发挥着关键作用。其中，在靶向免疫治疗中，利用靶向肽阻断免疫检查点与配体之间的结合，从而激活免疫系统来消除癌细胞，是一种先进的治疗策略。在这篇迷你综述中，我们总结了基于靶向肽的纳米材料的筛选、自组装和生物医学应用。此外，本迷你综述还总结了靶向肽的潜在应用和优化策略。
