Yao Man-Xue, Wang Yu-Ting, Zhou Nai-Hui
Department of Dermatology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215006, People's Republic of China.
Clin Cosmet Investig Dermatol. 2024 Feb 19;17:457-461. doi: 10.2147/CCID.S424707. eCollection 2024.
Multiple eruptive dermatofibroma (MEDF) is a rare presentation of dermatofibroma which is frequently associated with underlying diseases such as human immunodeficiency virus infection or systemic lupus erythematosus. It generally presents a characteristic histology with hyperplasia of the epidermis, prominent bundles of collagen and a diffuse proliferation of fibrocytes.
We report a case of MEDF in a 30-year-old man who presented with a large number of dark brownish red maculopapules distributed over the trunk and extremities for more than 10 years. According to the pathology, the patient was diagnosed with MEDF. Infections and autoimmune diseases were ruled out. As he had no clinical symptoms, and presented with lesions widely distributed over the body, we gave no special treatment, but suggested a regular examination.
Patients with MEDF usually have no pain and pruritus. If human immunodeficiency virus infection and systemic lupus erythematosus and other causes are ruled out, and lesions are widely distributed over the body, regular check-up is recommended without specific treatment.
多发性发疹性皮肤纤维瘤(MEDF)是皮肤纤维瘤的一种罕见表现形式,常与潜在疾病相关,如人类免疫缺陷病毒感染或系统性红斑狼疮。其通常呈现出特征性组织学表现,包括表皮增生、明显的胶原束和纤维细胞的弥漫性增生。
我们报告一例30岁男性的MEDF病例,该患者躯干和四肢出现大量暗棕红色斑丘疹,持续10余年。根据病理结果,患者被诊断为MEDF。排除了感染和自身免疫性疾病。由于他没有临床症状,且皮损广泛分布于全身,我们未给予特殊治疗,而是建议定期检查。
MEDF患者通常无疼痛和瘙痒症状。如果排除了人类免疫缺陷病毒感染和系统性红斑狼疮等病因,且皮损广泛分布于全身,建议定期检查,无需特殊治疗。