Sarkar Dibakar, Bhunia Anirban
Department of Chemical Sciences, Bose Institute, Unified Academic Campus, Sector V, Salt Lake EN 80, Kolkata 700 091, India.
ACS Bio Med Chem Au. 2023 Oct 31;4(1):4-19. doi: 10.1021/acsbiomedchemau.3c00055. eCollection 2024 Feb 21.
The pursuit of a novel structural motif that can shed light on the key functional attributes is a primary focus in the study of protein folding disorders. Decades of research on Alzheimer's disease (AD) have centered on the Amyloid β (Aβ) pathway, highlighting its significance in understanding the disorder. The diversity in the Aβ pathway and the possible silent tracks which are yet to discover, makes it exceedingly intimidating to the interdisciplinary scientific community. Over the course of AD research, Aβ has consistently been at the forefront of scientific inquiry and discussion. In this review, we epitomize the role of a potential structural motif (GxxxG motif) that may provide a new horizon to the Aβ conflict. We emphasize on how comprehensive understanding of this motif from a structure-function perspective may pave the way for designing novel therapeutics intervention in AD and related diseases.
寻找一种能够揭示关键功能属性的新型结构基序，是蛋白质折叠紊乱研究的主要重点。数十年来，对阿尔茨海默病（AD）的研究一直围绕淀粉样β蛋白（Aβ）途径展开，凸显了其在理解该疾病中的重要性。Aβ途径的多样性以及尚未被发现的潜在隐匿途径，令跨学科科学界望而生畏。在AD研究过程中，Aβ始终处于科学探究和讨论的前沿。在本综述中，我们概括了一种潜在结构基序（GxxxG基序）的作用，它可能为Aβ相关问题带来新的视角。我们强调，从结构-功能角度全面理解这一基序，可能为设计针对AD及相关疾病的新型治疗干预措施铺平道路。
