与静脉注射甲状腺激素相比，鞘内注射三碘甲状腺原氨酸对甲状腺功能减退大鼠的心率刺激作用更强。这为甲状腺激素作用于中枢神经系统部位提供了证据。
Intrathecal triiodothyronine administration causes greater heart rate stimulation in hypothyroid rats than intravenously delivered hormone. Evidence for a central nervous system site of thyroid hormone action.
作者信息
Goldman M, Dratman M B, Crutchfield F L, Jennings A S, Maruniak J A, Gibbons R
出版信息
J Clin Invest. 1985 Oct;76(4):1622-5. doi: 10.1172/JCI112146.
Abstract
To determine whether intracerebrally localized iodothyronines produce thyroid hormone-related functional effects, heart rate responses were compared in conscious hypothyroid rats given triiodothyronine (T3) by either the intrathecal or the intravenous route. A significant increase in heart rate occurred within 18 h after 1.5 nmol T3/100 g body wt was delivered intrathecally through a cannula previously placed in the lateral cerebral ventricle. Injection of the same T3 dose intravenously through an indwelling jugular catheter or injection of vehicle only by either route produced no significant increase in heart rate during the 48-h postinjection period of observation. These differences were observed even though integrated serum T3 concentrations were significantly lower after intrathecal than after intravenous T3 injection. The results indicate that thyroid hormone effects on heart rate are exerted within the brain as well as within the heart.
摘要
为了确定脑内局部的碘甲状腺原氨酸是否产生甲状腺激素相关的功能效应，在清醒的甲状腺功能减退大鼠中，比较通过鞘内或静脉途径给予三碘甲状腺原氨酸（T3）后的心率反应。通过先前置于侧脑室的套管鞘内给予1.5 nmol T3/100 g体重后18小时内，心率显著增加。通过留置颈静脉导管静脉注射相同剂量的T3或通过任一途径仅注射载体，在注射后48小时的观察期内心率均未显著增加。尽管鞘内注射T3后血清T3综合浓度显著低于静脉注射后，但仍观察到这些差异。结果表明，甲状腺激素对心率的影响在脑内和心脏内均可发挥作用。
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