• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

沿血管周围间隙的扩散张量成像（DTI-ALPS）评估年龄、性别和头围对健康受试者间质液动力学的影响。

Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects.

作者信息

Ozsahin Ilker, Zhou Liangdong, Wang Xiuyuan, Garetti Jacob, Jamison Keith, Xi Ke, Tanzi Emily, Jaywant Abhishek, Patchell Abigail, Maloney Thomas, de Leon Mony J, Kuceyeski Amy, Shah Sudhin A, Li Yi, Butler Tracy A

机构信息

Department of Radiology, Brain Health Imaging Institute, Weill Cornell Medicine, New York, NY, USA.

Operational Research Center in Healthcare, Near East University, Nicosia/TRNC, Turkey.

出版信息

J Alzheimers Dis Rep. 2024 Feb 20;8(1):355-361. doi: 10.3233/ADR-230143. eCollection 2024.

DOI:10.3233/ADR-230143
PMID:38405348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10894616/
Abstract

Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is a novel MRI method for assessing brain interstitial fluid dynamics, potentially indexing glymphatic function. Failed glymphatic clearance is implicated in Alzheimer's disease (AD) pathophysiology. We assessed the contribution of age and female sex (strong AD risk factors) to DTI-ALPS index in healthy subjects. We also for the first time assessed the effect of head size. In accord with prior studies, we show reduced DTI-ALPS index with aging, and in men compared to women. However, head size may be a major contributing factor to this counterintuitive sex difference.

摘要

沿血管周围间隙的扩散张量成像（DTI-ALPS）是一种用于评估脑间质液动力学的新型磁共振成像方法，可能是衡量类淋巴功能的指标。类淋巴清除功能障碍与阿尔茨海默病（AD）的病理生理过程有关。我们评估了年龄和女性性别（AD的强风险因素）对健康受试者DTI-ALPS指数的影响。我们还首次评估了头围大小的影响。与先前的研究一致，我们发现随着年龄增长，DTI-ALPS指数降低，且男性低于女性。然而，头围大小可能是导致这种与直觉相反的性别差异的主要因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4520/10894616/ac6abe5350f4/adr-8-adr230143-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4520/10894616/40c213e4ab0e/adr-8-adr230143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4520/10894616/fce818d0dacc/adr-8-adr230143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4520/10894616/ac6abe5350f4/adr-8-adr230143-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4520/10894616/40c213e4ab0e/adr-8-adr230143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4520/10894616/fce818d0dacc/adr-8-adr230143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4520/10894616/ac6abe5350f4/adr-8-adr230143-g003.jpg

相似文献

1
Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects.沿血管周围间隙的扩散张量成像（DTI-ALPS）评估年龄、性别和头围对健康受试者间质液动力学的影响。
J Alzheimers Dis Rep. 2024 Feb 20;8(1):355-361. doi: 10.3233/ADR-230143. eCollection 2024.
2
Diffusion Tensor Imaging Along the Perivascular Space for Characterizing Cerebral Interstitial Fluid Dynamics in Alzheimer's Disease: A Systematic Review and Meta-Analysis.沿血管周围间隙的扩散张量成像用于表征阿尔茨海默病中的脑间质液动力学：系统评价和荟萃分析
AJNR Am J Neuroradiol. 2025 Aug 4. doi: 10.3174/ajnr.A8953.
3
Association of magnetic resonance imaging glymphatic function with gray matter volume loss and cognitive impairment in Alzheimer's disease: a diffusion tensor image analysis along the perivascular space (DTI-ALPS) study.磁共振成像淋巴系统功能与阿尔茨海默病灰质体积减少和认知障碍的关联：一项沿血管周围间隙的扩散张量成像分析（DTI-ALPS）研究
Quant Imaging Med Surg. 2025 Jul 1;15(7):6160-6174. doi: 10.21037/qims-2025-96. Epub 2025 Jun 23.
4
Evaluation and interpretation of DTI-ALPS, a proposed surrogate marker for glymphatic clearance, in a large population-based sample.在一个基于人群的大样本中对DTI-ALPS（一种提议的类淋巴系统清除替代标志物）进行评估和解读。
Alzheimers Res Ther. 2025 Aug 19;17(1):191. doi: 10.1186/s13195-025-01842-3.
5
MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts.磁共振成像自由水介导了四个独立中老年队列中沿血管周围间隙的扩散张量图像分析与执行功能之间的关联。
Alzheimers Dement. 2025 Feb;21(2):e14453. doi: 10.1002/alz.14453. Epub 2024 Dec 30.
6
Altered along-the-perivascular space index in functional (psychogenic non-epileptic) seizures: A diffusion tensor imaging study of glymphatic system function.功能性（心因性非癫痫性）发作时血管周围间隙指数的改变：一项关于类淋巴系统功能的扩散张量成像研究
Epilepsia Open. 2025 Jul 19. doi: 10.1002/epi4.70089.
7
Diffusion tensor image analysis along the perivascular space index and visual analogue scales in female patients with patent foramen ovale and migraine perform better after percutaneous closure.卵圆孔未闭和偏头痛女性患者中，沿血管周围间隙指数和视觉模拟量表进行的扩散张量图像分析在经皮封堵术后表现更佳。
Quant Imaging Med Surg. 2025 Aug 1;15(8):6969-6980. doi: 10.21037/qims-2025-265. Epub 2025 Jul 30.
8
Noninvasive assessment of glymphatic dysfunction and IDH mutation in glioma with DTI-ALPS and DTI metrics.使用扩散张量成像-动脉自旋标记灌注成像（DTI-ALPS）和扩散张量成像（DTI）指标对胶质瘤中淋巴系统功能障碍和异柠檬酸脱氢酶（IDH）突变进行无创评估。
Quant Imaging Med Surg. 2025 Jun 6;15(6):5007-5022. doi: 10.21037/qims-2024-2710. Epub 2025 May 19.
9
Impaired glymphatic system function in relapsing-remitting multiple Sclerosis: Insights from diffusion tensor imaging along the perivascular space (DTI-ALPS).复发缓解型多发性硬化症中类淋巴系统功能受损：沿血管周围间隙的扩散张量成像（DTI-ALPS）研究洞察
Neuroscience. 2025 Aug 6;580:27-34. doi: 10.1016/j.neuroscience.2025.06.028. Epub 2025 Jun 14.
10
Unchanged Early Diffusion Tensor Imaging Along Perivascular Space Index After Amyloid-Targeting Disease-Modifying Therapy in Alzheimer's Disease: A Preliminary Study.阿尔茨海默病淀粉样蛋白靶向疾病修饰治疗后沿血管周围间隙指数的早期扩散张量成像无变化：一项初步研究。
medRxiv. 2025 May 9:2025.05.08.25327118. doi: 10.1101/2025.05.08.25327118.

引用本文的文献

1
DTI-ALPS index-assessed glymphatic dysfunction mediates Alzheimer's cognitive decline via amyloid-β-dependent pathways: multimodal PET/MRI study.弥散张量成像-阿尔茨海默病脑淋巴系统功能障碍评分指数评估的脑淋巴系统功能障碍通过淀粉样β蛋白依赖途径介导阿尔茨海默病认知衰退：多模态PET/MRI研究
Eur J Nucl Med Mol Imaging. 2025 Jul 18. doi: 10.1007/s00259-025-07445-2.
2
Diffusion along the perivascular space influenced by handedness and language lateralisation.受利手和语言侧化影响的沿血管周围间隙的扩散。
Brain Commun. 2025 Jun 24;7(4):fcaf252. doi: 10.1093/braincomms/fcaf252. eCollection 2025.
3
Sleep as a window into brain health: clinical implications of sleeping brain wave-structure associations.

本文引用的文献

1
Multimodal assessment of brain fluid clearance is associated with amyloid-beta deposition in humans.脑液清除的多模态评估与人类淀粉样蛋白-β沉积有关。
J Neuroradiol. 2024 Jun;51(4):101164. doi: 10.1016/j.neurad.2023.10.009. Epub 2023 Oct 30.
2
Evaluation of glymphatic system activity using diffusion tensor image analysis along the perivascular space and amyloid PET in older adults with objectively normal cognition: a preliminary study.利用沿血管周围间隙的扩散张量图像分析和淀粉样蛋白PET评估认知客观正常的老年人的类淋巴系统活性：一项初步研究。
Front Aging Neurosci. 2023 Jul 27;15:1221667. doi: 10.3389/fnagi.2023.1221667. eCollection 2023.
3
睡眠作为洞察大脑健康的窗口：睡眠脑电波结构关联的临床意义
Sleep. 2025 Aug 14;48(8). doi: 10.1093/sleep/zsaf127.
4
Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) in Normal Pressure Hydrocephalus: A Review of Recent Advances.正常压力脑积水沿血管周围间隙的扩散张量成像分析（DTI-ALPS）：近期进展综述
Cureus. 2025 Apr 7;17(4):e81830. doi: 10.7759/cureus.81830. eCollection 2025 Apr.
5
Correlation Between Dietary Nutrition and Glymphatic System Activity in Healthy Participants.健康受试者饮食营养与类淋巴系统活性之间的相关性
Cureus. 2025 Jan 22;17(1):e77860. doi: 10.7759/cureus.77860. eCollection 2025 Jan.
6
Evaluating the glymphatic system via magnetic resonance diffusion tensor imaging along the perivascular spaces in brain tumor patients.评估脑肿瘤患者血管周围间隙的磁共振扩散张量成像的糖液系统。
Jpn J Radiol. 2024 Oct;42(10):1146-1156. doi: 10.1007/s11604-024-01602-7. Epub 2024 May 31.
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma neurofilament light, a biomarker of injury severity.
使用沿血管周围间隙的扩散张量成像估计的类淋巴清除率在创伤性脑损伤后降低，且与血浆神经丝轻链相关，血浆神经丝轻链是损伤严重程度的生物标志物。
Brain Commun. 2023 Apr 25;5(3):fcad134. doi: 10.1093/braincomms/fcad134. eCollection 2023.
4
Association of Cognition and Brain Reserve in Aging and Glymphatic Function Using Diffusion Tensor Image-along the Perivascular Space (DTI-ALPS).基于脑内血管周围间隙的弥散张量成像（DTI-ALPS）评估认知与脑储备在衰老及脑淋巴系统功能中的作用。
Neuroscience. 2023 Aug 1;524:11-20. doi: 10.1016/j.neuroscience.2023.04.004. Epub 2023 Apr 6.
5
The aging of glymphatic system in human brain and its correlation with brain charts and neuropsychological functioning.人脑中糖脂系统的老化及其与脑图谱和神经心理学功能的相关性。
Cereb Cortex. 2023 Jun 8;33(12):7896-7903. doi: 10.1093/cercor/bhad086.
6
Neuroimaging uncovers distinct relationships of glymphatic dysfunction and motor symptoms in Parkinson's disease.神经影像学揭示了帕金森病中糖脂代谢功能障碍与运动症状的不同关系。
J Neurol. 2023 May;270(5):2649-2658. doi: 10.1007/s00415-023-11594-5. Epub 2023 Mar 1.
7
Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson's disease.沿血管周围间隙扩散作为帕金森病中胶质淋巴系统损伤的标志物。
NPJ Parkinsons Dis. 2022 Dec 21;8(1):174. doi: 10.1038/s41531-022-00437-1.
8
Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease.MRI 指数与轻度认知障碍和阿尔茨海默病中淀粉样蛋白沉积及认知的相关性研究。
Neurology. 2022 Dec 12;99(24):e2648-e2660. doi: 10.1212/WNL.0000000000201300.
9
Imaging perivascular space structure and function using brain MRI.利用脑 MRI 成像研究血管周围空间的结构和功能。
Neuroimage. 2022 Aug 15;257:119329. doi: 10.1016/j.neuroimage.2022.119329. Epub 2022 May 21.
10
The Influence of Demographics and Vascular Risk Factors on Glymphatic Function Measured by Diffusion Along Perivascular Space.人口统计学和血管危险因素对沿血管周围间隙扩散测量的类淋巴系统功能的影响。
Front Aging Neurosci. 2021 Jul 19;13:693787. doi: 10.3389/fnagi.2021.693787. eCollection 2021.