Perlaki Gábor, Dudás Barnabás, Horváth Réka, Orsi Gergely, Darnai Gergely, Arató Ákos, Nagy Szilvia Anett, Dóczi Tamás, Komoly Sámuel, Kovács Norbert, Janszky József
HUN-REN-PTE Clinical Neuroscience MR Research Group, H-7623 Pécs, Hungary.
Department of Neurology, Medical School, University of Pécs, H-7623 Pécs, Hungary.
Brain Commun. 2025 Jun 24;7(4):fcaf252. doi: 10.1093/braincomms/fcaf252. eCollection 2025.
The DTI-ALPS (diffusion tensor image analysis along the perivascular space index) has been tested in several diseases, but a limited number of studies are available in healthy normal populations. Given that some of the examined diseases show asymmetric features (e.g. Parkinson's disease, epilepsy) and considering that the DTI-ALPS is calculated from white matter regions involved in motor and language functions, our aim was to examine whether the index is influenced by handedness and/or functional language lateralisation. Eighty-two Caucasian adults (35 males; mean age: 26.91 ± 10.17, range: 18-66 years) were included in this retrospective cross-sectional study. Handedness was assessed by the Edinburgh Handedness Inventory, while language lateralisation was determined by functional MRI at 3T using a verbal fluency paradigm. The left- and right-hemispheric as well as the bilateral DTI-ALPS indices were calculated independently by two observers. Multiple linear regression corrected for age and sex indicated that handedness was inversely related to the left ALPS by Observer1 ( = 81, two-tailed = 0.030) and the bilateral ALPS by both observers ( = 82, = 0.025 and = 0.044), but not significantly related to the right ALPS. In females, multiple linear regression corrected for age indicated that language laterality index was inversely related to the left ALPS ( = 47, < 0.001) and the bilateral ALPS ( = 47, ≤ 0.003) by both observers, but not significantly associated with the right ALPS. In males, language laterality index was not related to any of the ALPS indices. Providing further insights into the normal DTI-ALPS patterns, our study supports the hypothesis that both language laterality and handedness can affect DTI-ALPS index that should be considered in future studies.
扩散张量图像沿脑周间隙指数（DTI-ALPS）已在多种疾病中进行了测试，但针对健康正常人群的研究数量有限。鉴于一些被检查的疾病表现出不对称特征（如帕金森病、癫痫），并且考虑到DTI-ALPS是根据涉及运动和语言功能的白质区域计算得出的，我们的目的是研究该指数是否受利手性和/或功能性语言偏侧化的影响。本回顾性横断面研究纳入了82名白种成年人（35名男性；平均年龄：26.91±10.17岁，范围：18 - 66岁）。利手性通过爱丁堡利手性量表进行评估，而语言偏侧化则通过3T功能磁共振成像使用言语流畅性范式来确定。两名观察者独立计算左、右半球以及双侧的DTI-ALPS指数。校正年龄和性别后的多元线性回归表明，观察者1计算的利手性与左侧ALPS呈负相关（n = 81，双尾p = 0.030），两名观察者计算的利手性与双侧ALPS均呈负相关（n = 82，p = 0.025和p = 0.044），但与右侧ALPS无显著相关性。在女性中，校正年龄后的多元线性回归表明，两名观察者计算的语言偏侧化指数与左侧ALPS呈负相关（n = 47，p < 0.001）以及与双侧ALPS呈负相关（n = 47，p ≤ 0.003），但与右侧ALPS无显著相关性。在男性中，语言偏侧化指数与任何ALPS指数均无相关性。我们的研究进一步深入了解了正常的DTI-ALPS模式，支持了语言偏侧化和利手性均可影响DTI-ALPS指数这一假设，未来研究应予以考虑。
