Zhang Yao, Zhang Ruiting, Ye Yongquan, Wang Shuyue, Jiaerken Yeerfan, Hong Hui, Li Kaicheng, Zeng Qingze, Luo Xiao, Xu Xiaopei, Yu Xinfeng, Wu Xiao, Yu Wenke, Zhang Minming, Huang Peiyu
Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
UIH America, Inc. Houston, TX, United States.
Front Aging Neurosci. 2021 Jul 19;13:693787. doi: 10.3389/fnagi.2021.693787. eCollection 2021.
Assessing glymphatic function using in-vivo imaging method is of great value for understanding its contribution to major brain diseases. In the present study, we aim to validate the association between a variety of risk factors and a potential index of glymphatic function-Diffusion Tensor Image Analysis Along the Perivascular Space (ALPS index). We enrolled 142 subjects from communities and performed multi-modality magnetic resonance imaging scans. The ALPS index was calculated from diffusion tensor imaging data, and its associations with demographic factors, vascular factors were investigated using regression analyses. We found that the ALPS index was negatively associated with age (β = -0.284, < 0.001). Compared to males, females had significantly higher ALPS index (β = -0.243, = 0.001). Hypertensive subjects had significantly lower ALPS index compared to non-hypertensive subjects (β = -0.189, = 0.013). Furthermore, venous disruption could decrease ALPS index (β = -0.215, = 0.003). In general, our results are in consistent with previous conceptions and results from animal studies about the pathophysiology of glymphatic dysfunction. Future studies utilizing this method should consider introducing the above-mentioned factors as important covariates.
使用体内成像方法评估脑淋巴系统功能对于理解其在主要脑部疾病中的作用具有重要价值。在本研究中，我们旨在验证多种风险因素与脑淋巴系统功能的一个潜在指标——沿血管周围间隙的扩散张量图像分析（ALPS指数）之间的关联。我们从社区招募了142名受试者，并进行了多模态磁共振成像扫描。从扩散张量成像数据计算出ALPS指数，并使用回归分析研究其与人口统计学因素、血管因素的关联。我们发现ALPS指数与年龄呈负相关（β = -0.284，< 0.001）。与男性相比，女性的ALPS指数显著更高（β = -0.243，= 0.001）。与非高血压受试者相比，高血压受试者的ALPS指数显著更低（β = -0.189，= 0.013）。此外，静脉中断会降低ALPS指数（β = -0.215，= 0.003）。总体而言，我们的结果与先前关于脑淋巴系统功能障碍病理生理学的概念和动物研究结果一致。未来使用这种方法的研究应考虑将上述因素作为重要的协变量引入。
