Krishnan Reshma Poothakulath, Pandiar Deepak, Ramani Pratibha
Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Ann Maxillofac Surg. 2023 Jul-Dec;13(2):248-251. doi: 10.4103/ams.ams_116_23. Epub 2023 Nov 20.
Sclerosing variant of adenoid cystic carcinoma (SACC) is a rare variant of adenoid cystic carcinoma (ACC) with only two cases in the literature. In this article, we report two cases of SACCs and attempt to explain the reason for sclerosis and its association with the disease outcome.
The first patient is a 43-year-old Dravidian Indian female with a chief complaint of pain and swelling in the right posterior cheek region of four months' duration. The second patient is an 8-year-old boy with a well-defined swelling in the left cheek region.
Both these cases were diagnosed as sclerosing variants of ACC.
The tumour was surgically excised for both patients.
Both the patients had no signs of residual disease/recurrence.
TAKE-AWAY LESSONS: We opine that the dense sclerotic stroma may have a preventing role in tumour cell growth and progression.
腺样囊性癌的硬化性变体（SACC）是腺样囊性癌（ACC）的一种罕见变体，文献中仅有两例报道。在本文中，我们报告了两例SACC病例，并试图解释硬化的原因及其与疾病转归的关系。
首例患者是一名43岁的德拉威族印度女性，主要症状为右侧后颊部疼痛和肿胀，持续4个月。第二例患者是一名8岁男孩，左侧颊部有一个边界清晰的肿块。
这两例均被诊断为ACC的硬化性变体。
两名患者均接受了手术切除肿瘤。
两名患者均无残留疾病/复发迹象。
我们认为致密的硬化性间质可能对肿瘤细胞的生长和进展具有抑制作用。
