Oxidative stress response: a critical factor affecting the ecological competitiveness of .

Oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. is linked to the occurrence and development of dental caries. The ability of to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of include synthesis of reductase, regulation of metal ions uptake, regulator PerR, transcription regulator Spx, extracellular uptake of glutathione, and other related signal transduction systems. Here, we provide an overview of how adapts to oxidative stress and its influence on oral microecology, which may offer novel options to investigate the cariogenic mechanisms of in the oral microenvironment, and new targets for the ecological prevention and treatment of dental caries.