Bouchon B, Portoukalian J, Bornet H
Biochem Int. 1985 Sep;11(3):415-24.
The influence of Graves' disease in human thyroid neutral glycosphingolipids was investigated. The major alteration was in the cerebroside fraction. Although the total amount of cerebroside was not different, the relative proportion of the bands of glucosylceramide separated on borated thin-layer plates was greatly modified in the disease. The band of glucosylceramide containing phytosphingosine and hydroxylated fatty acids decreased strongly, whereas the band with C18 sphingosine and normal fatty acids increased simultaneously. No change was observed in the content of galabiosylceramide. A slight elevation was seen in the amount of globoside at the expense of globotriaosylceramide.
研究了格雷夫斯病对人甲状腺中性糖鞘脂的影响。主要变化发生在脑苷脂部分。尽管脑苷脂的总量没有差异，但在硼酸盐薄层层析板上分离的葡萄糖神经酰胺条带的相对比例在疾病中发生了很大改变。含有植物鞘氨醇和羟基化脂肪酸的葡萄糖神经酰胺条带强烈减少，而含有C18鞘氨醇和正常脂肪酸的条带同时增加。半乳糖神经酰胺的含量未观察到变化。以球三糖神经酰胺为代价，球苷脂的量略有升高。
