Bouchon B, Portoukalian J, Bornet H
Biochem Int. 1985 Apr;10(4):531-8.
The major gangliosides of human thyroids were extracted, purified and then analyzed by gas-liquid chromatography. In normal thyroid, GM3 and GD3 represented about 80% of lipid-bound sialic acid. GM3 contained more than 50% of long-chain fatty acids, whereas GD3 contained mostly short ones. 4D hydroxy sphinganine represented 20% of long-chain base content in both cases. In pathological thyroids (Graves' disease, cancer, toxic adenoma), GM3 represented about 60% of lipid-bound sialic acid; its fatty acid content was mostly short chain fatty acids, as in normal GD3. 4D hydroxy sphinganine proportion was decreased.
提取、纯化人甲状腺的主要神经节苷脂，然后通过气液色谱法进行分析。在正常甲状腺中，GM3和GD3约占脂质结合唾液酸的80%。GM3含有超过50%的长链脂肪酸，而GD3主要含有短链脂肪酸。在这两种情况下，4D羟基鞘氨醇占长链碱基含量的20%。在病理性甲状腺（格雷夫斯病、癌症、毒性腺瘤）中，GM3约占脂质结合唾液酸的60%；其脂肪酸含量大多为短链脂肪酸，与正常GD3中的情况一样。4D羟基鞘氨醇的比例降低。
