National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, China.
College of Tobacco Science, Guizhou Key Laboratory for Tobacco Quality of Guizhou University, Guiyang, China.
Pest Manag Sci. 2024 Jul;80(7):3107-3115. doi: 10.1002/ps.8047. Epub 2024 Mar 12.
Ralstonia solanacearum, a notorious and refractory bacterial plant pathogen, threatens multiple vegetable crops and causes significant economic loss in agriculture. Long-term use of traditional medicines not only increases the problem of drug resistance, but also causes great environmental pollution. Therefore, there is an urgent need to develop new agents with high efficacy and low toxicity.
In this study, we have synthesized and characterized graphitic carbon nitride incorporated copper oxide composite (g-CN@CuO), which showed higher antimicrobial effect than graphitic carbon nitride nanosheets (g-CN nanosheets) and copper oxide nanoparticles (CuONPs). Ralstonia solanacearum exposed to g-CN@CuO exhibited higher levels of oxygen toxicity, cell membrane damage, DNA damage, motility disruption and even cell death compared to g-CN nanosheets and CuONPs. In addition, g-CN@CuO was more effective in the control of tobacco bacterial wilt than g-CN nanosheets and CuONPs.
Thus, this study provides a new perspective on g-CN@CuO control of bacterial diseases in crops, and the mechanism is related to the destruction of cell membrane damage and motility disruption. © 2024 Society of Chemical Industry.
茄科雷尔氏菌是一种臭名昭著且难以防治的细菌性植物病原体，它威胁着多种蔬菜作物，并在农业中造成重大经济损失。长期使用传统药物不仅会增加耐药性问题，还会造成严重的环境污染。因此，迫切需要开发高效低毒的新型药剂。
在本研究中，我们合成并表征了石墨相氮化碳负载氧化铜复合材料（g-CN@CuO），其表现出比石墨相氮化碳纳米片（g-CN 纳米片）和氧化铜纳米颗粒（CuONPs）更高的抗菌效果。与 g-CN 纳米片和 CuONPs 相比，暴露于 g-CN@CuO 的茄科雷尔氏菌表现出更高的氧毒性、细胞膜损伤、DNA 损伤、运动性破坏甚至细胞死亡水平。此外，g-CN@CuO 在控制烟草细菌性萎蔫方面比 g-CN 纳米片和 CuONPs 更有效。
因此，本研究为 g-CN@CuO 控制作物细菌病害提供了新视角，其机制与破坏细胞膜损伤和运动性破坏有关。© 2024 化学工业协会。
