Baylor University Medical Center, Dallas, Texas, USA.
Transpl Infect Dis. 2024 Apr;26(2):e14257. doi: 10.1111/tid.14257. Epub 2024 Feb 26.
We present a case of a 72-year-old liver transplant recipient 7 years prior who presents to our hospital with general malaise, fatigue, low-grade fevers, and watery diarrhea. He was found to have Astrovirus via PCR testing in a comprehensive stool panel. The patient's home mycophenolic acid was held upon admission, while cyclosporine was continued through his hospital stay. Generally, Astroviridae infection is a rarely identified cause of enteritis and even less so in the transplant population. Although reports have been published regarding devastating cases of encephalitis in immunocompromised patients, our patient did not exhibit these symptoms and draws into question the danger of this virus in other immunosuppressed populations. This case helps to better elucidate which patient populations should be approached with caution in the setting of Astroviridae infection.
我们报告了 1 例 72 岁的肝移植受者，该患者在 7 年前接受了肝移植，目前因全身不适、乏力、低热和水样腹泻而到我院就诊。通过全面的粪便检测，我们发现患者存在星状病毒感染，通过 PCR 检测确诊。患者入院后停用了霉酚酸酯，环孢素则继续使用。一般来说，星状病毒感染很少被认为是肠炎的病因，在移植人群中更是如此。尽管已有免疫功能低下患者发生脑炎的严重病例报道，但我们的患者没有出现这些症状，这使得该病毒在其他免疫抑制人群中的危害性值得探讨。该病例有助于更好地阐明在星状病毒感染的情况下，哪些患者人群应谨慎对待。
