Low J A, Galbraith R S, Muir D W, Broekhoven L H, Wilkinson J W, Karchmar E J
Dev Med Child Neurol. 1985 Oct;27(5):578-87. doi: 10.1111/j.1469-8749.1985.tb14129.x.
A total of 364 selected high-risk premature and mature infants were studied prospectively to assess the relationship between fetal-newborn complications and motor and cognitive deficits identified during the first year of life. Deficits occurred in 24 per cent of the children: 14 per cent had one or more major deficit and the other 10 per cent had one or more minor deficit. Prematurity was one of the fetal-newborn complications not associated with deficits at one year. Complications that were associated with deficits included fetal hypoxia, respiratory difficulties, infection and newborn encephalopathy. There was also a significant association between fetal hypoxia, newborn respiratory complications, infection and newborn encephalopathy, which is in keeping with the concept that the first three may be mechanisms in CNS injury and subsequent deficits, while newborn encephalopathy reflects the injury and is an important predictor of such deficits.
对总共364名选定的高危早产儿和足月儿进行了前瞻性研究，以评估胎儿-新生儿并发症与出生后第一年出现的运动和认知缺陷之间的关系。24%的儿童出现了缺陷：14%有一项或多项主要缺陷，另外10%有一项或多项次要缺陷。早产是与一岁时无缺陷相关的胎儿-新生儿并发症之一。与缺陷相关的并发症包括胎儿缺氧、呼吸困难、感染和新生儿脑病。胎儿缺氧、新生儿呼吸并发症、感染和新生儿脑病之间也存在显著关联，这与前三者可能是中枢神经系统损伤及随后缺陷的机制，而新生儿脑病反映了损伤且是此类缺陷的重要预测指标这一概念相符。
